OBJECTIVES: This study was performed to assess the extent of functional involvement of the affected hemisphere in Sturge Weber syndrome in comparison with the uninvolved hemisphere. To this end beta activity in the electroencephalogram (EEG) was measured, both before and after administration of diazepam intravenously (i.v.). METHODS: In 9 patients asymmetry in beta band activity was studied before and after diazepam administration. Several beta bands and asymmetry parameters were calculated. beta band asymmetries were compared with structural abnormalities (magnetic resonance imaging, MRI). RESULTS: Total beta activity was reduced in the involved hemisphere in all patients after diazepam administration. In 3 patients functional abnormalities were found in brain regions that were structurally intact. CONCLUSIONS: Decreased diazepam-enhanced beta activity in the EEG is a sensitive criterion of functional abnormality. In patients with subtle structural abnormalities diazepam-enhanced EEG may have added value in diagnosing functional involvement and in monitoring disease progression in patients.
OBJECTIVES: This study was performed to assess the extent of functional involvement of the affected hemisphere in Sturge Weber syndrome in comparison with the uninvolved hemisphere. To this end beta activity in the electroencephalogram (EEG) was measured, both before and after administration of diazepam intravenously (i.v.). METHODS: In 9 patients asymmetry in beta band activity was studied before and after diazepam administration. Several beta bands and asymmetry parameters were calculated. beta band asymmetries were compared with structural abnormalities (magnetic resonance imaging, MRI). RESULTS: Total beta activity was reduced in the involved hemisphere in all patients after diazepam administration. In 3 patientsfunctional abnormalities were found in brain regions that were structurally intact. CONCLUSIONS: Decreased diazepam-enhanced beta activity in the EEG is a sensitive criterion of functional abnormality. In patients with subtle structural abnormalitiesdiazepam-enhanced EEG may have added value in diagnosing functional involvement and in monitoring disease progression in patients.
Authors: Malgorzata Dymerska; Anna Y Kirkorian; Elizabeth A Offermann; Doris D Lin; Anne M Comi; Bernard A Cohen Journal: J Pediatr Date: 2017-07-12 Impact factor: 4.406
Authors: Elizabeth A Offermann; Aditya Sreenivasan; M Robert DeJong; Doris D M Lin; Charles E McCulloch; Melissa G Chung; Anne M Comi Journal: Pediatr Neurol Date: 2017-05-08 Impact factor: 3.372
Authors: Joshua B Ewen; Eric H Kossoff; Nathan E Crone; Doris D M Lin; Balaji M Lakshmanan; Lisa M Ferenc; Anne M Comi Journal: Clin Neurophysiol Date: 2009-07-08 Impact factor: 3.708