Literature DB >> 12088676

Links between innate and adaptive immunity via type I interferon.

Agnes Le Bon1, David F Tough.   

Abstract

Type I interferon (IFN-alpha/beta) is expressed rapidly following exposure to a wide variety of infectious agents and plays a key role in innate control of virus replication. Recent studies have demonstrated that dendritic cells both produce IFN-alpha/beta and undergo maturation in response to IFN-alpha/beta. Moreover, IFN-alpha/beta has been shown to potently enhance immune responses in vivo through the stimulation of dendritic cells. These findings indicate that IFN-alpha/beta serves as a signal linking innate and adaptive immunity.

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Year:  2002        PMID： 12088676     DOI： 10.1016/s0952-7915(02)00354-0

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  222 in total

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10.  An immune competent mouse model for the characterization of recombinant measles vaccines.

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