Exploitation of kinetic differences between normal and malignant cells.

Some of the differences in the proliferative kinetics of normal and malignant tissues may be used to increase radiation damage to tumor cells. Of these various possibilities, some are still at a theoretical stage (mainly because there are no means of obtaining the needed data) but others, notably those involving a combination of cycle-linked chemotherapeutic and/or radiosensitizing drugs with radiation, may be exploitable now with the expectation of clinical benefit.