| Literature DB >> 12088446 |
Preecha Phuwapraisirisan1, Shigeki Matsunaga, Rob W M van Soest, Nobuhiro Fusetani.
Abstract
Bioassay-directed fractionation of the lipophilic extract of the marine sponge Mycale izuensis led to the isolation of cytotoxic mycalolides including a new compound, 30,32-dihydroxymycalolide A (1). Its structure including absolute stereochemistry was deduced by spectroscopic and chemical methods. Compound 1 was cytotoxic against HeLa cells with an IC(50) value of 2.6 ng/mL.Entities:
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Year: 2002 PMID： 12088446 DOI： 10.1021/np010663+
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050