Literature DB >> 12087925

Synthesis and evaluation of anticancer activity of some imidazothiazolyl, imidazobenzothiazolyl and dihydroimidazothiazolyl coumarins.

Kagne Srimanth1, Vedula Rajeswar Rao, Devarakonda R Krishna.   

Abstract

A series of 6-(2H-1-benzopyran-2-one-3-yl)imidazo[2,1-b]thiazoles (1), 2-(2H-1-benzopyran-2-one-3-yl)imidazo[2,1-b]benzothiazoles (2) and 3-(2H-1-benzopyran-2-one-3-yl)-5,6-dihydroimidazo[2,1-b]thiazoles (3) have been synthesized and evaluated for anticancer activity in vitro. The compounds showed very good activity against different tumor cell lines.

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Year:  2002        PMID： 12087925     DOI： 10.1055/s-0031-1299903

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  4 in total

1.  N-(3-Oxo-1-thia-4-aza-spiro-[4.5]dec-4-yl)-6-phenyl-imidazo[2,1-b][1,3]thia-zole-3-acetamide hemihydrate.

Authors:  Mehmet Akkurt; Serife Pınar Yalçın; Nuray Ulusoy Güzeldemirci; Orhan Büyükgüngör
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-04-10

2.  A novel inhibitor of Rho GDP-dissociation inhibitor α improves the therapeutic efficacy of paclitaxel in Lewis lung carcinoma.

Authors:  Xing Chen Peng; Xu Xia Chen; Y U Zhang; Hai Jun Wang; You Feng
Journal:  Biomed Rep       Date:  2015-05-27

3.  SKLB-163, a new benzothiazole-2-thiol derivative, exhibits potent anticancer activity by affecting RhoGDI/JNK-1 signaling pathway.

Authors:  X Peng; G Xie; Z Wang; H Lin; T Zhou; P Xiang; Y Jiang; S Yang; Y Wei; L Yu; Y Zhao
Journal:  Cell Death Dis       Date:  2014-03-27       Impact factor: 8.469

4.  Microwave-assisted synthesis and antitumor evaluation of a new series of thiazolylcoumarin derivatives.

Authors:  Moustafa T Gabr; Nadia S El-Gohary; Eman R El-Bendary; Mohamed M El-Kerdawy; Nanting Ni
Journal:  EXCLI J       Date:  2017-08-30       Impact factor: 4.068
  4 in total

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