Literature DB >> 12086835

Polymer-supported reagents for methylphosphorylation and phosphorylation of carbohydrates.

Keykavous Parang1.   

Abstract

Two polymer-supported reagents for methylphosphorylation and phosphorylation of carbohydrates have been developed. p-Hydroxybenzyl alcohol and beta-mercaptoethanol were immobilized on cross-linked divinylbenzene-polystyrene copolymer and conjugated with methyl N,N-diisopropylchlorophosphoramidite. Carbohydrates were reacted with polymer-bound phosphitylating reagents. Further oxidation, with or without the methoxy group deprotection, and cleavage yielded methylphosphorylated or phosphorylated carbohydrates, respectively.

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Year:  2002        PMID： 12086835     DOI： 10.1016/s0960-894x(02)00266-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Solid-Phase Synthesis of 5'-O-β,γ-Methylenetriphosphate Derivatives of Nucleosides and Evaluation of Their Inhibitory Activity Against HIV-1 Reverse Transcriptase.

Authors:  Yousef Ahmadibeni; Chandravanu Dash; Stuart F J Le Grice; Keykavous Parang
Journal:  Tetrahedron Lett       Date:  2010-06-02       Impact factor: 2.415

2.  Synthesis of nucleoside 5'-O-alpha,beta-methylene-beta-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase.

Authors:  Y Ahmadibeni; C Dash; M J Hanley; S F J Le Grice; H K Agarwal; K Parang
Journal:  Org Biomol Chem       Date:  2010-01-13       Impact factor: 3.876

3.  Synthesis of polymer-bound 4-acetoxy-3-phenylbenzaldehyde derivatives: applications in solid-phase organic synthesis.

Authors:  Anil Kumar; Guofeng Ye; Yousef Ahmadibeni; Keykavous Parang
Journal:  J Org Chem       Date:  2006-09-29       Impact factor: 4.354

4.  Synthesis of nucleoside mono-, di-, and triphosphoramidates from solid-phase cyclosaligenyl phosphitylating reagents.

Authors:  Yousef Ahmadibeni; Rakesh K Tiwari; Gongqin Sun; Keykavous Parang
Journal:  Org Lett       Date:  2009-05-21       Impact factor: 6.005
  4 in total

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