Literature DB >> 12086823

A polymer-supported [1,3,2]oxazaphospholidine for the conversion of isothiocyanates to isocyanides and their subsequent use in an ugi reaction.

Steven V Ley1, Stephen J Taylor.   

Abstract

The design and synthesis of a new polymer supported reagent for the clean conversion of isothiocyanates to isocyanides under microwave conditions was accomplished. The structurally diverse isocyanides generated were used in an Ugi 3CC, allowing the rapid generation of 2-isoindolinone-7-carboxamide analogues.

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Year:  2002        PMID： 12086823     DOI： 10.1016/s0960-894x(02)00269-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Advances in organic synthesis using polymer-supported reagents and scavengers under microwave irradiation.

Authors:  Sukanta Bhattacharyya
Journal:  Mol Divers       Date:  2005       Impact factor: 2.943

2.  Microwaves, supported-reagents and parallel synthesis: isocyanide and ester synthesis.

Authors:  Stefano Crosignani; Delphine Launay; Bruno Linclau; Mark Bradley
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

3.  The rapid generation of isothiocyanates in flow.

Authors:  Marcus Baumann; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2013-08-08       Impact factor: 2.883
  3 in total

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