BACKGROUND: To characterize the impact of brain death (BD) on endothelial dysfunction after cardiac transplantation we investigated coronary circulation and vasomotor function in a canine model. METHODS: Left ventricular pressure-volume data (conductance catheter) and coronary blood flow (CBF) were monitored continuously. Endothelium-dependent vasodilatation after acetylcholine and endothelium-independent vasodilation after sodium nitroprusside were assessed before and 3 hr after BD induction (inflation of a subdural balloon). RESULTS: BD led to an initial hyperdynamic reaction with significant (P<0.05) increase of CBF. After 3 hr, CBF decreased significantly (P<0.05). Although before BD, application of acetylcholine led to a monophasic vasodilatative response, after BD a short mild vasodilatation was followed by a longer vasoconstriction. Endothelium-independent vasodilatation remained unchanged. CONCLUSIONS: BD affects coronary circulation by two means: (1) impairment of CBF to decrease in parallel in afterload with consecutive hemodynamic deterioration and (2) severe endothelial dysfunction that may be a contributing factor to posttransplant outcome.
BACKGROUND: To characterize the impact of brain death (BD) on endothelial dysfunction after cardiac transplantation we investigated coronary circulation and vasomotor function in a canine model. METHODS: Left ventricular pressure-volume data (conductance catheter) and coronary blood flow (CBF) were monitored continuously. Endothelium-dependent vasodilatation after acetylcholine and endothelium-independent vasodilation after sodium nitroprusside were assessed before and 3 hr after BD induction (inflation of a subdural balloon). RESULTS: BD led to an initial hyperdynamic reaction with significant (P<0.05) increase of CBF. After 3 hr, CBF decreased significantly (P<0.05). Although before BD, application of acetylcholine led to a monophasic vasodilatative response, after BD a short mild vasodilatation was followed by a longer vasoconstriction. Endothelium-independent vasodilatation remained unchanged. CONCLUSIONS: BD affects coronary circulation by two means: (1) impairment of CBF to decrease in parallel in afterload with consecutive hemodynamic deterioration and (2) severe endothelial dysfunction that may be a contributing factor to posttransplant outcome.
Authors: Qi Cheng; Kunal Patel; Biao Lei; Lindsay Rucker; D Patterson Allen; Peng Zhu; Chentha Vasu; Paulo N Martins; Martin Goddard; Satish N Nadig; Carl Atkinson Journal: Am J Transplant Date: 2018-04-10 Impact factor: 8.086
Authors: Carl Atkinson; Bernhard Floerchinger; Fei Qiao; Sarah Casey; Tucker Williamson; Ellen Moseley; Serban Stoica; Martin Goddard; Xupeng Ge; Stefan G Tullius; Stephen Tomlinson Journal: Circulation Date: 2013-02-26 Impact factor: 29.690
Authors: Laura Kummer; Marcin Zaradzki; Vijith Vijayan; Rawa Arif; Markus A Weigand; Stephan Immenschuh; Andreas H Wagner; Jan Larmann Journal: Front Physiol Date: 2020-05-08 Impact factor: 4.566
Authors: Sevil Korkmaz-Icöz; Pengyu Zhou; Yuxing Guo; Sivakkanan Loganathan; Paige Brlecic; Tamás Radovits; Alex Ali Sayour; Mihály Ruppert; Gábor Veres; Matthias Karck; Gábor Szabó Journal: Stem Cell Res Ther Date: 2021-02-24 Impact factor: 6.832