| Literature DB >> 12084796 |
Richard Marcotte1, Eugenia Wang.
Abstract
Forty years after its discovery, replicative senescence remains a rich source of information about cell-cycle regulation and the progression from a normal to a transformed phenotype. Effectors of this growth-arrested state are being discovered at a great pace. This review discusses the latest findings on the players responsible for establishing replicative senescence, as well as the associated telomere shortening.Keywords: Non-programmatic
Mesh:
Substances:
Year: 2002 PMID: 12084796 DOI: 10.1093/gerona/57.7.b257
Source DB: PubMed Journal: J Gerontol A Biol Sci Med Sci ISSN: 1079-5006 Impact factor: 6.053