Literature DB >> 12084579

Promoter II of the bovine acetyl-coenzyme A carboxylase-alpha-encoding gene is widely expressed and strongly active in different cells.

Jianqiang Mao1, Hans-Martin Seyfert.   

Abstract

Three promoters express the bovine gene encoding the enzyme acetyl-CoA carboxylase-alpha (ACC alpha) known to be rate-limiting for fatty acid synthesis. Our sequence of promoter II shows that PII is evolutionary conserved, unlike PI or PIII. In vivo expression of PII reveals little tissue-specific restrictions. The proximal 133 bp of this promoter are sufficient for a strong basal expression in different cell lines.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12084579     DOI： 10.1016/s0167-4781(02)00369-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  5 in total

1.  The SNPs in the ACACA gene are effective on fatty acid composition in Holstein milk.

Authors:  Hirokazu Matsumoto; Kenta Sasaki; Takuya Bessho; Eiji Kobayashi; Tsuyoshi Abe; Shinji Sasazaki; Kenji Oyama; Hideyuki Mannen
Journal:  Mol Biol Rep       Date:  2012-06-21       Impact factor: 2.316

2.  Induction of transcripts derived from promoter III of the acetyl-CoA carboxylase-alpha gene in mammary gland is associated with recruitment of SREBP-1 to a region of the proximal promoter defined by a DNase I hypersensitive site.

Authors:  Michael C Barber; Amanda J Vallance; Helen T Kennedy; Maureen T Travers
Journal:  Biochem J       Date:  2003-10-15       Impact factor: 3.857

3.  Human acetyl-CoA carboxylase 1 gene: presence of three promoters and heterogeneity at the 5'-untranslated mRNA region.

Authors:  Jianqiang Mao; Subrahmanyam S Chirala; Salih J Wakil
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-16       Impact factor: 11.205

4.  Interaction of C/EBP-beta and NF-Y factors constrains activity levels of the nutritionally controlled promoter IA expressing the acetyl-CoA carboxylase-alpha gene in cattle.

Authors:  Xuanming Shi; Cornelia C Metges; Hans-Martin Seyfert
Journal:  BMC Mol Biol       Date:  2012-06-27       Impact factor: 2.946

5.  Specificity protein 1 regulates gene expression related to fatty acid metabolism in goat mammary epithelial cells.

Authors:  Jiangjiang Zhu; Yuting Sun; Jun Luo; Min Wu; Jianhua Li; Yanhong Cao
Journal:  Int J Mol Sci       Date:  2015-01-14       Impact factor: 5.923
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.