| Literature DB >> 12083758 |
Bashir M Rezk1, Guido R M M Haenen, Wim J F van der Vijgh, Aalt Bast.
Abstract
Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone. The potent activity of 2,6-dihydroxyacetophenone is due to stabilisation of its radical via tautomerisation. The antioxidant pharmacophore in the dihydrochalcone phloretin, i.e., the 2,6-dihydroxyacetophenone group, is different from the antioxidant pharmacophores previously reported in flavonoids. (c) 2002 Elsevier Science (USA).Entities:
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Year: 2002 PMID： 12083758 DOI： 10.1016/s0006-291x(02)00618-6
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575