Literature DB >> 12082234

The collagenous lesion scar--an obstacle for axonal regeneration in brain and spinal cord injury.

S Hermanns1, N Klapka, H W Müller.   

Abstract

After CNS trauma a sheet-like, collagen type IV (Coll IV) immunopositive basement membrane (BM) develops in the lesion zone as well as at newly formed blood vessels. The basic scaffold of this BM is composed of Coll IV, laminin and nidogen but numerous other proteins some of which are discussed to be inhibitory for axonal regeneration, i.e. chondroitin- and heparansufate-proteoglycans, are associated with BM. This review will focus on the collagenous wound healing scar, discuss its composition and summarize the experimental results that demonstrate its role in the failure of axonal regeneration in the injured mammalian CNS.

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Year:  2001        PMID： 12082234

Source DB:  PubMed          Journal:  Restor Neurol Neurosci        ISSN： 0922-6028            Impact factor:   2.406


  21 in total

1.  Development of a tissue-engineered composite implant for treating traumatic paraplegia in rats.

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Journal:  Eur Spine J       Date:  2005-11-15       Impact factor: 3.134

2.  How Plastic Are Pericytes?

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Journal:  Stem Cells Dev       Date:  2017-06-13       Impact factor: 3.272

3.  Enhanced survival and neurite network formation of human umbilical cord blood neuronal progenitors in three-dimensional collagen constructs.

Authors:  Marian M Bercu; Hadar Arien-Zakay; Dana Stoler; Shimon Lecht; Peter I Lelkes; Simcha Samuel; Reuven Or; Arnon Nagler; Philip Lazarovici; Uriel Elchalal
Journal:  J Mol Neurosci       Date:  2012-12-12       Impact factor: 3.444

4.  Permissive Schwann cell graft/spinal cord interfaces for axon regeneration.

Authors:  Ryan R Williams; Martha Henao; Damien D Pearse; Mary Bartlett Bunge
Journal:  Cell Transplant       Date:  2013-10-22       Impact factor: 4.064

5.  Tuba1a gene expression is regulated by KLF6/7 and is necessary for CNS development and regeneration in zebrafish.

Authors:  Matthew B Veldman; Michael A Bemben; Daniel Goldman
Journal:  Mol Cell Neurosci       Date:  2010-02-01       Impact factor: 4.314

6.  Region-specific differentiation potential of adult rat spinal cord neural stem/precursors and their plasticity in response to in vitro manipulation.

Authors:  Iris Kulbatski; Charles H Tator
Journal:  J Histochem Cytochem       Date:  2009-01-05       Impact factor: 2.479

7.  Resection of glial scar following spinal cord injury.

Authors:  Alexandre Rasouli; Nitin Bhatia; Paul Dinh; Kim Cahill; Sourabh Suryadevara; Ranjan Gupta
Journal:  J Orthop Res       Date:  2009-07       Impact factor: 3.494

8.  Molecular and histologic outcomes following spinal cord injury in spiny mice, Acomys cahirinus.

Authors:  Kristi A Streeter; Michael D Sunshine; Jason O Brant; Aaron G W Sandoval; Malcolm Maden; David D Fuller
Journal:  J Comp Neurol       Date:  2019-12-19       Impact factor: 3.215

Review 9.  Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury.

Authors:  Andrew D Gaudet; Phillip G Popovich; Matt S Ramer
Journal:  J Neuroinflammation       Date:  2011-08-30       Impact factor: 8.322

10.  Iron oxide nanoparticles and magnetic field exposure promote functional recovery by attenuating free radical-induced damage in rats with spinal cord transection.

Authors:  Ajay Pal; Anand Singh; Tapas C Nag; Parthaprasad Chattopadhyay; Rashmi Mathur; Suman Jain
Journal:  Int J Nanomedicine       Date:  2013-06-21
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