Differential inflammatory and immunological responses in tissue regeneration and repair.

Repair and regeneration, contrasting resolutions to injury, evoke distinct inflammatory responses. Wound repair evokes a more robust peripheral leukocytosis and is accompanied by a larger inflammatory infiltrate into the wound site. Proliferation of thymocytes and splenocytes was enhanced following injury; however, the ability to be stimulated by myoblasts in coculure is lost by splenocytes harvested from rats undergoing wound repair. These data reflect differences in inflammatory and immunological responses between repair and regeneration and suggest potentially important dialogues occur between injured tissues and inflammatory cells that direct the course of injury resolution.