| Literature DB >> 12081698 |
J D Wilkinson1, S Shaw, K E Andersen, F M Brandao, D P Bruynzeel, M Bruze, J M G Camarasa, T L Diepgen, G Ducombs, P J Frosch, A Goossens, J-M Lachappelle, A Lahti, T Menné, S Seidenari, A Tosti, J E Wahlberg.
Abstract
A 10-year multicentre analysis of the frequency of sensitivity to common preservatives collected in 16 centres in 11 countries has shown stable but persisting high levels of sensitivity to formaldehyde and 5-chloro-2-methyl-4-isothiazolin-3-one + 2-methyl-4-isothiazolin-3-one (MCI/MI). It has also revealed a significant increase in the level of reactivity to methyldibromoglutaronitrile (MDBGN) from 0.7% in 1991 to 3.5% in 2000. The current high level of sensitivity to MDBGN requires an urgent safety re-evaluation and risk assessment update along with consideration of immediate lowering of use concentrations, especially in leave-on products.Entities:
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Year: 2002 PMID： 12081698 DOI： 10.1034/j.1600-0536.2002.460404.x
Source DB: PubMed Journal: Contact Dermatitis ISSN： 0105-1873 Impact factor: 6.600