Literature DB >> 12081178

Lactic acidosis and abnormal liver function in advanced HIV disease.

M Shahmanesh1, J Cartledge, R Miller.   

Abstract

A 48 year old man receiving HAART presented with late stage HIV disease, non-specific symptoms, a normal sized liver, ascites, and lactic acidosis. Following a failed liver biopsy worsening acidosis developed, requiring ICU support. Progressive liver failure occurred. Endoscopy showed oesophageal varices and a transjugular liver biopsy showed non-cirrhotic cholestasis; findings that were ascribed to HAART.

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Year:  2002        PMID： 12081178      PMCID： PMC1744453          DOI： 10.1136/sti.78.2.139

Source DB:  PubMed          Journal:  Sex Transm Infect        ISSN： 1368-4973            Impact factor:   3.519


  8 in total

1.  Hyperlactataemia and hepatic steatosis: mitochondrial toxicity of nucleoside reverse transcriptase inhibitors.

Authors:  D Pao; C Watson; B Peters; S B Lucas; R F Miller
Journal:  Sex Transm Infect       Date:  2001-10       Impact factor: 3.519

2.  Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia.

Authors:  A Carr; A Morey; P Mallon; D Williams; D R Thorburn
Journal:  Lancet       Date:  2001-05-05       Impact factor: 79.321

3.  Fatal haemorrhage following liver biopsy in patients with HIV infection.

Authors:  D R Churchill; D Mann; R J Coker; R F Miller; G Glazer; R D Goldin; S B Lucas; J N Weber; K M De Cock
Journal:  Genitourin Med       Date:  1996-02

Review 4.  Mitochondrial toxicity and HIV therapy.

Authors:  A J White
Journal:  Sex Transm Infect       Date:  2001-06       Impact factor: 3.519

5.  Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy.

Authors:  M John; C B Moore; I R James; D Nolan; R P Upton; E J McKinnon; S A Mallal
Journal:  AIDS       Date:  2001-04-13       Impact factor: 4.177

6.  Hyperlactatemia and hepatic abnormalities in 10 human immunodeficiency virus-infected patients receiving nucleoside analogue combination regimens.

Authors:  J T Lonergan; C Behling; H Pfander; T I Hassanein; W C Mathews
Journal:  Clin Infect Dis       Date:  2000-07-26       Impact factor: 9.079

7.  Fulminant hepatic failure associated with 2',3'-dideoxyinosine (ddI).

Authors:  K K Lai; D L Gang; J K Zawacki; T P Cooley
Journal:  Ann Intern Med       Date:  1991-08-15       Impact factor: 25.391

8.  Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy.

Authors:  I S Fortgang; P C Belitsos; R E Chaisson; R D Moore
Journal:  Am J Gastroenterol       Date:  1995-09       Impact factor: 10.864
  8 in total

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