Literature DB >> 12080361

Transplantation for accidental acute high-dose total body neutron- and gamma-radiation exposure.

S Chiba1, A Saito, S Ogawa, K Takeuchi, K Kumano, S Seo, T Suzuki, Y Tanaka, T Saito, K Izutsu, K Yuji, S Masuda, S Futami, M Nishida, G Suzuki, R P Gale, M Fukayama, K Maekawa, H Hirai.   

Abstract

Accidental exposure to acute high-dose total body neutron radiation is rare. We report a 35-year-old man exposed to a total body dose of 5.4 Gy neutron- and 8.5-13 Gy gamma-radiation in a radiation criticality accident. He received a blood stem cell transplant from his HLA-identical sister. There was bone marrow recovery with complete donor chimerism. Random chromatid breaks were observed in donor cells suggesting a bystander effect of neutron exposure. The subject died 82 days after the accident (75 days post transplant) from multi-organ failure.

Entities:  

Mesh：

Year:  2002        PMID： 12080361     DOI： 10.1038/sj.bmt.1703568

Source DB:  PubMed          Journal:  Bone Marrow Transplant        ISSN： 0268-3369            Impact factor:   5.483


  12 in total

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7.  Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia.

Authors:  Hidekazu Nishikii; Naoki Kurita; Atsushi Shinagawa; Tatsuhiro Sakamoto; Manabu Kusakabe; Yasuhisa Yokoyama; Takayasu Kato; Mamiko Sakata-Yanagimoto; Naoshi Obara; Yuichi Hasegawa; Naoya Nakamura; Shigeru Chiba
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8.  Severe acute radiation syndrome: treatment of a lethally 60Co-source irradiated accident victim in China with HLA-mismatched peripheral blood stem cell transplantation and mesenchymal stem cells.

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Journal:  J Radiat Res       Date:  2013-08-26       Impact factor: 2.724

9.  Neutron exposures in human cells: bystander effect and relative biological effectiveness.

Authors:  Isheeta Seth; Jeffrey L Schwartz; Robert D Stewart; Robert Emery; Michael C Joiner; James D Tucker
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Review 10.  Ionizing Radiation and Human Health: Reviewing Models of Exposure and Mechanisms of Cellular Damage. An Epigenetic Perspective.

Authors:  Ernesto Burgio; Prisco Piscitelli; Lucia Migliore
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