| Literature DB >> 12078511 |
Abstract
Bile pigments and CO are formed in the course of heme degradation by the isozymes and are biologically active moieties. In the course of heme degradation the chelated iron is also released. Heme and iron are prooxidants, whereas bile pigments are antioxidants. In addition, CO functions as a signal molecule and HO-2 may serve as an intracellular "sink" for NO. In the balance, the published data suggest that the HO system functions in cellular defense mechanisms. The methods described in this chapter can be used to assess the tissue/cell toxicity of chemicals in general, and as pertains to the defense activity of HO-1, specifically.Entities:
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Year: 2002 PMID： 12078511 DOI： 10.1016/s0076-6879(02)53062-7
Source DB: PubMed Journal: Methods Enzymol ISSN： 0076-6879 Impact factor: 1.600