OBJECTIVES: To assess the strength of the associations between HLA shared epitopes (SE) and rheumatoid arthritis (RA) susceptibility, articular disease severity, and extra-articular features in Mediterranean European populations. METHODS: One hundred and seventy-four Greek RA patients and 103 controls were evaluated. Data were then included in a meta-analysis of 9 studies of Mediterranean European populations (959 RA patients and 1,405 controls). RESULTS: In our study population, SE alleles were significantly more common in RA patients than in controls (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.4-4.3). Larsen radiologic score was predicted by SE and disease duration. SE did not increase the risk of any extra-articular manifestation. The meta-analysis showed a pooled OR of 3.7 (95% CI, 2.6-5.2) for susceptibility to RA conferred by SE (OR, 3.4 v 3.9 in Greek v non-Greek populations). CONCLUSIONS: SE determine articular destruction without increasing the risk of extra-articular manifestations. The immunogenetic associations of RA susceptibility are consistent, but their strength may depend on the SE prevalence in different ethnic groups. Copyright 2002, Elsevier Science (USA). All rights reserved.
OBJECTIVES: To assess the strength of the associations between HLA shared epitopes (SE) and rheumatoid arthritis (RA) susceptibility, articular disease severity, and extra-articular features in Mediterranean European populations. METHODS: One hundred and seventy-four Greek RApatients and 103 controls were evaluated. Data were then included in a meta-analysis of 9 studies of Mediterranean European populations (959 RApatients and 1,405 controls). RESULTS: In our study population, SE alleles were significantly more common in RApatients than in controls (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.4-4.3). Larsen radiologic score was predicted by SE and disease duration. SE did not increase the risk of any extra-articular manifestation. The meta-analysis showed a pooled OR of 3.7 (95% CI, 2.6-5.2) for susceptibility to RA conferred by SE (OR, 3.4 v 3.9 in Greek v non-Greek populations). CONCLUSIONS: SE determine articular destruction without increasing the risk of extra-articular manifestations. The immunogenetic associations of RA susceptibility are consistent, but their strength may depend on the SE prevalence in different ethnic groups. Copyright 2002, Elsevier Science (USA). All rights reserved.
Authors: Georgios Christopoulos; V Christopoulou; J G Routsias; A Babionitakis; C Antoniadis; G Vaiopoulos Journal: Clin Rheumatol Date: 2016-10-08 Impact factor: 2.980
Authors: Paula I Burgos; Zenoria L Causey; Ashutosh Tamhane; James M Kelley; Elizabeth E Brown; Laura B Hughes; Maria I Danila; Amalia van Everdingen; Doyt L Conn; Beth L Jonas; Leigh F Callahan; Edwin A Smith; Richard D Brasington; Larry W Moreland; Désirée M van der Heijde; Graciela S Alarcón; S Louis Bridges Journal: Arthritis Res Ther Date: 2010-05-05 Impact factor: 5.156