Literature DB >> 12076537

P450 BM3: the very model of a modern flavocytochrome.

Andrew W Munro1, David G Leys, Kirsty J McLean, Ker R Marshall, Tobias W B Ost, Simon Daff, Caroline S Miles, Stephen K Chapman, Dominikus A Lysek, Christopher C Moser, Christopher C Page, P Leslie Dutton.   

Abstract

Flavocytochrome P450 BM3 is a bacterial P450 system in which a fatty acid hydroxylase P450 is fused to a mammalian-like diflavin NADPH-P450 reductase in a single polypeptide. The enzyme is soluble (unlike mammalian P450 redox systems) and its fusion arrangement affords it the highest catalytic activity of any P450 mono-oxygenase. This article discusses the fundamental properties of P450 BM3 and how progress with this model P450 has affected our comprehension of P450 systems in general.

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Year:  2002        PMID： 12076537     DOI： 10.1016/s0968-0004(02)02086-8

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  72 in total

1.  StyA1 and StyA2B from Rhodococcus opacus 1CP: a multifunctional styrene monooxygenase system.

Authors:  Dirk Tischler; René Kermer; Janosch A D Gröning; Stefan R Kaschabek; Willem J H van Berkel; Michael Schlömann
Journal:  J Bacteriol       Date:  2010-07-30       Impact factor: 3.490

2.  Insights into electron leakage in the reaction cycle of cytochrome P450 BM3 revealed by kinetic modeling and mutagenesis.

Authors:  Joseph B Lim; Kimberly A Barker; Kristen A Eller; Linda Jiang; Veronica Molina; Jessica F Saifee; Hadley D Sikes
Journal:  Protein Sci       Date:  2015-09-09       Impact factor: 6.725

3.  Functional characterisation of an engineered multidomain human P450 2E1 by molecular Lego.

Authors:  Michael Fairhead; Silva Giannini; Elizabeth M J Gillam; Gianfranco Gilardi
Journal:  J Biol Inorg Chem       Date:  2005-11-09       Impact factor: 3.358

4.  Thermal inactivation of the reductase domain of cytochrome P450 BM3.

Authors:  Arvind P Jamakhandi; Brandon C Jeffus; Vandana R Dass; Grover P Miller
Journal:  Arch Biochem Biophys       Date:  2005-07-15       Impact factor: 4.013

5.  Protein stability promotes evolvability.

Authors:  Jesse D Bloom; Sy T Labthavikul; Christopher R Otey; Frances H Arnold
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-31       Impact factor: 11.205

6.  Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain.

Authors:  Shengying Li; Larissa M Podust; David H Sherman
Journal:  J Am Chem Soc       Date:  2007-10-04       Impact factor: 15.419

7.  Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.

Authors:  Mohammad M Haque; Mekki Bayachou; Jesus Tejero; Claire T Kenney; Naw M Pearl; Sang-Choul Im; Lucy Waskell; Dennis J Stuehr
Journal:  FEBS J       Date:  2014-10-25       Impact factor: 5.542

8.  Regulation of FMN subdomain interactions and function in neuronal nitric oxide synthase.

Authors:  Robielyn P Ilagan; Jesús Tejero; Kulwant S Aulak; Sougata Sinha Ray; Craig Hemann; Zhi-Qiang Wang; Mahinda Gangoda; Jay L Zweier; Dennis J Stuehr
Journal:  Biochemistry       Date:  2009-05-12       Impact factor: 3.162

9.  Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.

Authors:  Kirsty J McLean; Paul Carroll; D Geraint Lewis; Adrian J Dunford; Harriet E Seward; Rajasekhar Neeli; Myles R Cheesman; Laurent Marsollier; Philip Douglas; W Ewen Smith; Ida Rosenkrands; Stewart T Cole; David Leys; Tanya Parish; Andrew W Munro
Journal:  J Biol Chem       Date:  2008-09-24       Impact factor: 5.157

10.  Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran.

Authors:  Z Jane Wang; Hans Renata; Nicole E Peck; Christopher C Farwell; Pedro S Coelho; Frances H Arnold
Journal:  Angew Chem Int Ed Engl       Date:  2014-05-06       Impact factor: 15.336
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