Literature DB >> 120765

Duration of immunity following a single vaccination with irradiated sporozoites of Plasmodium berghei.

N D Pacheco, E McConnell, R L Beaudoin.   

Abstract

A rodent model of sporozoite immunization against malaria based on a single immunizing dose is described. The duration of protective immunity was measured as a function of dose, and the results suggest that the percentage of protection follows a bimodal distribution. The first peak occurs between days 7-12 after immunization, while the second peak occurs at approximately 28 days. Although the percentage of protection declines steadily after the second peak, some immunity was detectable as long as 140 days after immunization with the higher doses.

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Mesh：

Year:  1979        PMID： 120765      PMCID： PMC2395719     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  3 in total

1.  Immunization of monkeys against Plasmodium cynomolgi by X-irradiated sporozoites.

Authors:  W E Collins; P G Contacos
Journal:  Nat New Biol       Date:  1972-04-12

2.  Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei. IV. Dose response, specificity and humoral immunity.

Authors:  R Nussenzweig; J Vanderberg; H Most
Journal:  Mil Med       Date:  1969-09       Impact factor: 1.437

3.  Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei.

Authors:  R S Nussenzweig; J Vanderberg; H Most; C Orton
Journal:  Nature       Date:  1967-10-14       Impact factor: 49.962
  3 in total
  5 in total

1.  CD8+ T-cell mediated anti-malaria protection induced by malaria vaccines; assessment of hepatic CD8+ T cells by SCBC assay.

Authors:  Jing Zhou; Alaina Kaiser; Colin Ng; Rachel Karcher; Tim McConnell; Patrick Paczkowski; Cristina Fernandez; Min Zhang; Sean Mackay; Moriya Tsuji
Journal:  Hum Vaccin Immunother       Date:  2017-07-03       Impact factor: 3.452

2.  Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.

Authors:  D Lys Guilbride; Pawel Gawlinski; Patrick D L Guilbride
Journal:  PLoS One       Date:  2010-05-19       Impact factor: 3.240

3.  Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.

Authors:  Nathan W Schmidt; Rebecca L Podyminogin; Noah S Butler; Vladimir P Badovinac; Brad J Tucker; Keith S Bahjat; Peter Lauer; Arturo Reyes-Sandoval; Claire L Hutchings; Anne C Moore; Sarah C Gilbert; Adrian V Hill; Lyric C Bartholomay; John T Harty
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-09       Impact factor: 11.205

4.  Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites.

Authors:  Noah S Butler; Nathan W Schmidt; John T Harty
Journal:  J Immunol       Date:  2010-01-22       Impact factor: 5.422

5.  Effect of route of Mycobacterium bovis BCG administration on induction of suppression of sporozoite immunity in rodent malaria.

Authors:  L L Smrkovski
Journal:  Infect Immun       Date:  1981-01       Impact factor: 3.441
  5 in total

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