| Literature DB >> 12075402 |
Zhenhe Suo1, Bjørn Risberg, Mats G Karlsson, Kenneth Villman, Eva Skovlund, Jahn M Nesland.
Abstract
Expression of EGF, HB-EGF, TGF-alpha, HRG-alpha, HRG-beta1, and HRG-beta3 in 100 frozen breast carcinoma materials was immunohistochemically studied. Among these tumors, 67% were positive for EGF, 53% for HB-EGF, 57% for TGF-alpha, 60% for HRG-alpha, 53% for HRG-beta1, and 63% for HRG-beta3 in the neoplastic epithelial cells. No significant associations between expression of the growth factors and clinicopathological features like tumor size, histologic grade, node status, ploidy, ER status, and c-erbB-4 expression were observed, with the exceptions that significant relations were present between EGF expression and tumor size (p = 0.01) and between HRG-beta3 expression and node status (p = 0.02). The expressions of these growth factors showed no association with cancer-specific survival by the Kaplan Meier analysis.Entities:
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Year: 2002 PMID： 12075402 DOI： 10.1177/106689690201000202
Source DB: PubMed Journal: Int J Surg Pathol ISSN： 1066-8969 Impact factor: 1.271