Literature DB >> 12075138

Lifespan does not measure ageing.

Axel Kowald1.   

Abstract

The Gompertz equation, which describes the increase of mortality over time, is often used to measure the rate of the ageing process. However, a recent article argued that it is incorrect to use the function for this purpose and that its use should therefore be discouraged (Driver 2001). I believe that this conclusion is based on misunderstandings and that the Gompertz function (if used appropriately) is actually well suited to measure the ageing rate. Here I will solve the 'paradox' posed by the author and argue that it is actually lifespan that is inadequate to measure ageing and not the Gompertz function.

Mesh:

Year:  2002        PMID: 12075138     DOI: 10.1023/a:1015659527013

Source DB:  PubMed          Journal:  Biogerontology        ISSN: 1389-5729            Impact factor:   4.277


  10 in total

Review 1.  Longevity and ageing: appraising the evolutionary consequences of growing old.

Authors:  Michael B Bonsall
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-01-29       Impact factor: 6.237

2.  Food availability affects adult survival trajectories depending on early developmental conditions.

Authors:  Michael Briga; Egbert Koetsier; Jelle J Boonekamp; Blanca Jimeno; Simon Verhulst
Journal:  Proc Biol Sci       Date:  2017-01-11       Impact factor: 5.349

3.  Supplementation of deprenyl attenuates age associated alterations in rat cerebellum.

Authors:  Manju V Subramanian; T J James
Journal:  Mol Biol Rep       Date:  2010-03-07       Impact factor: 2.316

Review 4.  Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.

Authors:  Edward O List; Lucila Sackmann-Sala; Darlene E Berryman; Kevin Funk; Bruce Kelder; Elahu S Gosney; Shigeru Okada; Juan Ding; Diana Cruz-Topete; John J Kopchick
Journal:  Endocr Rev       Date:  2010-12-01       Impact factor: 19.871

5.  Age-related protective effect of deprenyl on changes in the levels of diagnostic marker enzymes and antioxidant defense enzymes activities in cerebellar tissue in Wistar rats.

Authors:  Manju V Subramanian; T J James
Journal:  Cell Stress Chaperones       Date:  2010-03-13       Impact factor: 3.667

6.  Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging.

Authors:  Anirban Paul; Amy Belton; Sanjay Nag; Ian Martin; Michael S Grotewiel; Atanu Duttaroy
Journal:  Mech Ageing Dev       Date:  2007-11-04       Impact factor: 5.432

7.  Lifespan extension and paraquat resistance in a ubiquinone-deficient Escherichia coli mutant depend on transcription factors ArcA and TdcA.

Authors:  Stavros Gonidakis; Steven E Finkel; Valter D Longo
Journal:  Aging (Albany NY)       Date:  2011-03       Impact factor: 5.682

Review 8.  Which Is the Most Significant Cause of Aging?

Authors:  Stefan I Liochev
Journal:  Antioxidants (Basel)       Date:  2015-12-17

9.  Variation in actuarial senescence does not reflect life span variation across mammals.

Authors:  Guillaume Péron; Jean-François Lemaître; Victor Ronget; Morgane Tidière; Jean-Michel Gaillard
Journal:  PLoS Biol       Date:  2019-09-13       Impact factor: 8.029

10.  Sex-related differences in aging rate are associated with sex chromosome system in amphibians.

Authors:  Hugo Cayuela; Jean-François Lemaître; Jean-Paul Léna; Victor Ronget; Iñigo Martínez-Solano; Erin Muths; David S Pilliod; Benedikt R Schmidt; Gregorio Sánchez-Montes; Jorge Gutiérrez-Rodríguez; Graham Pyke; Kurt Grossenbacher; Omar Lenzi; Jaime Bosch; Karen H Beard; Lawrence L Woolbright; Brad A Lambert; David M Green; Nathalie Jreidini; Justin M Garwood; Robert N Fisher; Kathleen Matthews; David Dudgeon; Anthony Lau; Jeroen Speybroeck; Rebecca Homan; Robert Jehle; Eyup Başkale; Emiliano Mori; Jan W Arntzen; Pierre Joly; Rochelle M Stiles; Michael J Lannoo; John C Maerz; Winsor H Lowe; Andrés Valenzuela-Sánchez; Ditte G Christiansen; Claudio Angelini; Jean-Marc Thirion; Juha Merilä; Guarino R Colli; Mariana M Vasconcellos; Taissa C V Boas; Ísis da C Arantes; Pauline Levionnois; Beth A Reinke; Cristina Vieira; Gabriel A B Marais; Jean-Michel Gaillard; David A W Miller
Journal:  Evolution       Date:  2022-01-07       Impact factor: 4.171

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.