| Literature DB >> 12074842 |
Kanji Mori1, Yonehiro Kanemura, Hirokazu Fujikawa, Atsuhisa Nakano, Hideyasu Ikemoto, Isao Ozaki, Tsuyoshi Matsumoto, Kazuyoshi Tamura, Masayuki Yokota, Norio Arita.
Abstract
Brain-specific angiogenesis inhibitor 1 (BAI1) is a p53-target gene specifically expressed in the brain. We examined the distribution of the endogenous BAI1 protein in normal human brain tissue using a polyclonal antibody against the extracellular region of BAI1. Immunohistochemical study demonstrated that BAI1 was expressed in neuronal cells of the cerebral cortex but not in astrocytes. BAI1 protein was localized in the cellular cytoplasm and membrane. It was predominantly localized in the cellular membrane when expressed in cultured cells by means of gene transfection. BAI1 protein may play an important role in neuronal functions such as synapse formation and signal transduction.Entities:
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Year: 2002 PMID： 12074842 DOI： 10.1016/s0168-0102(02)00018-4
Source DB: PubMed Journal: Neurosci Res ISSN： 0168-0102 Impact factor: 3.304