Literature DB >> 12074542

Overcoming the inflammatory toxicity of cationic gene vectors.

Yadi Tan1, Leaf Huang.   

Abstract

Cationic lipid- and polymer-based vectors are the most extensively studied synthetic gene vectors. These vectors have been widely used in animal models and some have been tested in clinical trials. The clinical progress of these vectors has been slowed by their inflammatory toxicity. This review summarizes the observations, the mechanisms, and various strategies employed to overcome the inflammatory toxicity of cationic gene vectors.

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Year:  2002        PMID： 12074542     DOI： 10.1080/10611860290016757

Source DB:  PubMed          Journal:  J Drug Target        ISSN： 1026-7158            Impact factor:   5.121


  7 in total

Review 1.  Electroporation of the vasculature and the lung.

Authors:  David A Dean
Journal:  DNA Cell Biol       Date:  2003-12       Impact factor: 3.311

Review 2.  Designer lipids for drug delivery: from heads to tails.

Authors:  Aditya G Kohli; Paul H Kierstead; Vincent J Venditto; Colin L Walsh; Francis C Szoka
Journal:  J Control Release       Date:  2014-05-06       Impact factor: 9.776

3.  Endovascular embolization of the swine rete mirabile with Eudragit-E 100 polymer.

Authors:  H Arakawa; Y Murayama; C R Davis; D L Howard; W L Baumgardner; M P Marks; H M Do
Journal:  AJNR Am J Neuroradiol       Date:  2007 Jun-Jul       Impact factor: 3.825

4.  Plasmid CpG depletion improves degree and duration of tumor gene expression after intravenous administration of polyplexes.

Authors:  Holger K de Wolf; Nina Johansson; Anh-Thy Thong; Cor J Snel; Enrico Mastrobattista; Wim E Hennink; Gert Storm
Journal:  Pharm Res       Date:  2008-03-04       Impact factor: 4.200

Review 5.  Lipid-Based Nanocarriers for RNA Delivery.

Authors:  Hui Yi Xue; Pengbo Guo; Wu-Cheng Wen; Ho Lun Wong
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116

Review 6.  MicroRNA-Based Therapy in Animal Models of Selected Gastrointestinal Cancers.

Authors:  Jana Merhautova; Regina Demlova; Ondrej Slaby
Journal:  Front Pharmacol       Date:  2016-09-27       Impact factor: 5.810

7.  Cross-linked small polyethylenimines: while still nontoxic, deliver DNA efficiently to mammalian cells in vitro and in vivo.

Authors:  Mini Thomas; Qing Ge; James J Lu; Jianzhu Chen; Alexander M Klibanov
Journal:  Pharm Res       Date:  2005-03       Impact factor: 4.200
  7 in total

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