PURPOSE: To assess the control of corneal hydration in patients with diabetes during a contact lens-induced hypoxia. METHODS: Corneal stress was induced in 15 patients with diabetes and 23 healthy patients by having them wear contact lenses for 2 hours. Pachymetries were measured and corneal parameters (percentage recovery per hour [PRPH], time for deswelling [T99%] and induced swelling [IS]) were calculated. In the mean time, tears were collected to assess the activity of lactate dehydrogenase (LDH), and a specular microscopy (SM) was performed. RESULTS: In patients with diabetes, PRPH, T99%, and LDH activity were statistically significantly modified (p < 0.05), whereas IS and SM were not. CONCLUSION: This decreased ability to recover the initial corneal thickness after a transient edema caused by hypoxia confirms the enzymatic dysfunction of the endothelial pumps that are partly caused by a shift toward anaerobic metabolism.
PURPOSE: To assess the control of corneal hydration in patients with diabetes during a contact lens-induced hypoxia. METHODS: Corneal stress was induced in 15 patients with diabetes and 23 healthy patients by having them wear contact lenses for 2 hours. Pachymetries were measured and corneal parameters (percentage recovery per hour [PRPH], time for deswelling [T99%] and induced swelling [IS]) were calculated. In the mean time, tears were collected to assess the activity of lactate dehydrogenase (LDH), and a specular microscopy (SM) was performed. RESULTS: In patients with diabetes, PRPH, T99%, and LDH activity were statistically significantly modified (p < 0.05), whereas IS and SM were not. CONCLUSION: This decreased ability to recover the initial corneal thickness after a transient edema caused by hypoxia confirms the enzymatic dysfunction of the endothelial pumps that are partly caused by a shift toward anaerobic metabolism.
Authors: Jonathan H Lass; Tonya D Riddlesworth; Robin L Gal; Craig Kollman; Beth A Benetz; Francis W Price; Alan Sugar; Mark A Terry; Mark Soper; Roy W Beck Journal: Ophthalmology Date: 2014-11-15 Impact factor: 12.079
Authors: Mark A Terry; Anthony J Aldave; Loretta B Szczotka-Flynn; Wendi Liang; Allison R Ayala; Maureen G Maguire; Christopher Croasdale; Yassine J Daoud; Steven P Dunn; Caroline K Hoover; Marian S Macsai; Thomas F Mauger; Sudeep Pramanik; George O D Rosenwasser; Jennifer Rose-Nussbaumer; R Doyle Stulting; Alan Sugar; Elmer Y Tu; David D Verdier; Sonia H Yoo; Jonathan H Lass Journal: Ophthalmology Date: 2018-08-09 Impact factor: 12.079
Authors: Anthony J Aldave; Mark A Terry; Loretta B Szczotka-Flynn; Wendi Liang; Allison R Ayala; Maureen G Maguire; Robert C O'Brien; Beth Ann Benetz; John E Bokosky; Steven P Dunn; Thomas E Gillette; Kristin M Hammersmith; David R Hardten; Bennie H Jeng; Marc F Jones; Richard L Lindstrom; Kenneth J Maverick; Verinder S Nirankari; Matthew S Oliva; Irving M Raber; Christopher J Rapuano; George O D Rosenwasser; Kevin W Ross; John W Seedor; Neda Shamie; Christopher G Stoeger; Shachar Tauber; Woodford S Van Meter; David D Verdier; Jonathan H Lass Journal: Am J Ophthalmol Date: 2019-03-06 Impact factor: 5.258
Authors: Jonathan H Lass; Beth Ann Benetz; Sanjay V Patel; Loretta B Szczotka-Flynn; Robert O'Brien; Allison R Ayala; Maureen G Maguire; Yassine J Daoud; Mark A Greiner; Sadeer B Hannush; W Barry Lee; Thomas F Mauger; Harry J Menegay; Mark D Mifflin; Michael B Raizman; Jennifer Rose-Nussbaumer; Robert L Schultze; Gregory A Schmidt; Alan Sugar; Mark A Terry; David D Verdier Journal: JAMA Ophthalmol Date: 2019-02-01 Impact factor: 7.389
Authors: X Adnan; Marwan Suheimat; Nathan Efron; Katie Edwards; Nicola Pritchard; Ankit Mathur; Edward A H Mallen; David A Atchison Journal: Biomed Opt Express Date: 2015-02-04 Impact factor: 3.732