| Literature DB >> 12072368 |
Abstract
Recent evidence suggests that there may be specificities in the signal transduction pathways activated by different Toll-like receptors (TLRs), with different sets of genes being induced by TLR-4 when compared with TLR-2. These differences may be because of different signalling adapters, with MyD88 being used by several TLRs, and the adapter MyD88-adapter-like (Mal) being recruited specifically by TLR-4. The set of genes being induced may be tailored for the subsequent elimination of the pathogen being recognized, as a result of differences in signal transduction pathways activated by TLRs. These findings may ultimately explain how dendritic cells control specific T-cell responses.Entities:
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Year: 2002 PMID： 12072368 DOI： 10.1016/s1471-4906(02)02222-6
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687