Literature DB >> 12072235

Immune modulation: the genetic approach.

M-H Pinard-van der Laan1.   

Abstract

As part of a comprehensive strategy to combat diseases, improving genetically resistance to diseases and therefore immune capacities of animals is more and more desirable. However, research is still needed to develop genetic tools that may be used. In this search, lines selected for various immune responses are used to study relevant immune markers. Chickens have been selected for six generations for three different in vivo immune responses: high antibody response, high cell-mediated immune response and high phagocytic activity. Each line, selected for one trait, showed significant increase in immune capacity for this trait. In addition, results showed clearly independence between the three immune responses analyzed, meaning that a global approach is needed to improve immune capacity. Selected lines allow to follow genetic markers linked to immune response genes. In the different lines, different patterns in MHC gene frequency were observed and MHC alleles differed in their effects according to the immune trait. Some correlations were found between immune responses and production traits. The selected lines will be used to find other "known" immune response genes or "anonymous" genetic markers, which may become the future tools to modulate immune responsiveness of animals.

Entities:  

Mesh：

Year:  2002        PMID： 12072235     DOI： 10.1016/s0165-2427(02)00075-2

Source DB:  PubMed          Journal:  Vet Immunol Immunopathol        ISSN： 0165-2427            Impact factor:   2.046


  9 in total

1.  Different serum haemolytic complement levels in indigenous chickens from Benin, Bolivia, Cameroon, India and Tanzania.

Authors:  R Baelmans; H K Parmentier; H M J Udo; P Dorny; F Demey; D Berkvens
Journal:  Trop Anim Health Prod       Date:  2004-11       Impact factor: 1.559

2.  Haemolytic complement activity and humoral immune responses to sheep red blood cells in indigenous chickens and in eight German Dahlem Red chicken lines with different combinations of major genes (dwarf, naked neck and frizzled) of tropical interest.

Authors:  R Baelmans; H K Parmentier; M G B Nieuwland; P Dorny; F Demey; D Berkvens
Journal:  Trop Anim Health Prod       Date:  2005-04       Impact factor: 1.559

3.  Diversity and evolution of the highly polymorphic tandem repeat LEI0258 in the chicken MHC-B region.

Authors:  Olympe Chazara; Chi-Sheng Chang; Nicolas Bruneau; Khalid Benabdeljelil; Jean-Claude Fotsa; Boniface B Kayang; N'Goran E Loukou; Richard Osei-Amponsah; Valentine Yapi-Gnaore; Issaka A K Youssao; Chih-Feng Chen; Marie-Hélène Pinard-van der Laan; Michèle Tixier-Boichard; Bertrand Bed'hom
Journal:  Immunogenetics       Date:  2013-03-26       Impact factor: 2.846

4.  Assessment of trade-offs between feed efficiency, growth-related traits, and immune activity in experimental lines of layer chickens.

Authors:  Tatiana Zerjal; Sonja Härtle; David Gourichon; Vanaïque Guillory; Nicolas Bruneau; Denis Laloë; Marie-Hélène Pinard-van der Laan; Sascha Trapp; Bertrand Bed'hom; Pascale Quéré
Journal:  Genet Sel Evol       Date:  2021-05-06       Impact factor: 4.297

5.  Immunity traits in pigs: substantial genetic variation and limited covariation.

Authors:  Laurence Flori; Yu Gao; Denis Laloë; Gaëtan Lemonnier; Jean-Jacques Leplat; Angélique Teillaud; Anne-Marie Cossalter; Joëlle Laffitte; Philippe Pinton; Christiane de Vaureix; Marcel Bouffaud; Marie-José Mercat; François Lefèvre; Isabelle P Oswald; Jean-Pierre Bidanel; Claire Rogel-Gaillard
Journal:  PLoS One       Date:  2011-07-29       Impact factor: 3.240

6.  Aspergillus fumigatus in Poultry.

Authors:  Pascal Arné; Simon Thierry; Dongying Wang; Manjula Deville; Guillaume Le Loc'h; Anaïs Desoutter; Françoise Féménia; Adélaïde Nieguitsila; Weiyi Huang; René Chermette; Jacques Guillot
Journal:  Int J Microbiol       Date:  2011-06-14

Review 7.  Ecological feedbacks can reduce population-level efficacy of wildlife fertility control.

Authors:  Jason I Ransom; Jenny G Powers; N Thompson Hobbs; Dan L Baker
Journal:  J Appl Ecol       Date:  2013-10-15       Impact factor: 6.528

8.  Correlated effects of selection for immunity in White Leghorn chicken lines on natural antibodies and specific antibody responses to KLH and M. butyricum.

Authors:  Giulietta Minozzi; Henk K Parmentier; Sandrine Mignon-Grasteau; Mike Gb Nieuwland; Bertrand Bed'hom; David Gourichon; Francis Minvielle; Marie-Helen Pinard-van der Laan
Journal:  BMC Genet       Date:  2008-01-14       Impact factor: 2.797

9.  Association between Single Nucleotide Polymorphisms of the Major Histocompatibility Complex Class II Gene and Newcastle Disease Virus Titre and Body Weight in Leung Hang Khao Chickens.

Authors:  A Molee; K Kongroi; P Kuadsantia; C Poompramun; B Likitdecharote
Journal:  Asian-Australas J Anim Sci       Date:  2016-01       Impact factor: 2.509
  9 in total

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