Literature DB >> 12069962

In vitro activities of iboga alkaloid congeners coronaridine and 18-methoxycoronaridine against Leishmania amazonensis.

Jan Carlo Delorenzi1, Leonardo Freire-de-Lima, Cerli R Gattass, Deise de Andrade Costa, Liwen He, Martin E Kuehne, Elvira M B Saraiva.   

Abstract

In previous studies, we demonstrated the leishmanicide effect of coronaridine, a natural indole alkaloid isolated from stem bark of Peschiera australis (Delorenzi et al., Antimicrob. Agents Chemother. 45:1349-1354, 2001). In this study we show the leishmanicidal effect of the synthetic coronaridine and its racemic 18-methoxylated analog, 18-methoxycoronaridine. Both alkaloids revealed a potent leishmanicide effect against Leishmania amazonensis, a causative agent of cutaneous and diffuse cutaneous leishmaniasis in the New World. Despite their potent leishmanicide effect, both alkaloids were neither toxic to murine macrophages nor did they modulate their oxidative or cytokine production responses.

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Year:  2002        PMID： 12069962      PMCID： PMC127312          DOI： 10.1128/AAC.46.7.2111-2115.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

1.  Evidence for roles of kappa-opioid and NMDA receptors in the mechanism of action of ibogaine.

Authors:  S D Glick; I M Maisonneuve; S M Pearl
Journal:  Brain Res       Date:  1997-02-28       Impact factor: 3.252

2.  Leishmania spp.: mechanisms of toxicity of nitrogen oxidation products.

Authors:  J Mauël; A Ransijn
Journal:  Exp Parasitol       Date:  1997-10       Impact factor: 2.011

3.  Ibogaine-like effects of noribogaine in rats.

Authors:  S D Glick; S M Pearl; J Cai; I M Maisonneuve
Journal:  Brain Res       Date:  1996-03-25       Impact factor: 3.252

4.  Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells.

Authors:  Y Belkaid; B Butcher; D L Sacks
Journal:  Eur J Immunol       Date:  1998-04       Impact factor: 5.532

5.  Metacyclogenesis modulates the ability of Leishmania promastigotes to induce IL-12 production in human mononuclear cells.

Authors:  A Sartori; M A Oliveira; P Scott; G Trinchieri
Journal:  J Immunol       Date:  1997-09-15       Impact factor: 5.422

6.  Ervatamia coronaria: chemical constituents and some pharmacological activities.

Authors:  A T Henriques; A A Melo; P R Moreno; L L Ene; J A Henriques; E E Schapoval
Journal:  J Ethnopharmacol       Date:  1996-01       Impact factor: 4.360

Review 7.  Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years.

Authors:  J D Berman
Journal:  Clin Infect Dis       Date:  1997-04       Impact factor: 9.079

8.  Migration inhibitory factor induces killing of Leishmania major by macrophages: dependence on reactive nitrogen intermediates and endogenous TNF-alpha.

Authors:  S Jüttner; J Bernhagen; C N Metz; M Röllinghoff; R Bucala; A Gessner
Journal:  J Immunol       Date:  1998-09-01       Impact factor: 5.422

9.  Ibogaine neurotoxicity: a re-evaluation.

Authors:  H H Molinari; I M Maisonneuve; S D Glick
Journal:  Brain Res       Date:  1996-10-21       Impact factor: 3.252

10.  Regulation of the expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages.

Authors:  L Proudfoot; A V Nikolaev; G J Feng; W Q Wei; M A Ferguson; J S Brimacombe; F Y Liew
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205
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  4 in total

1.  Resveratrol is active against Leishmania amazonensis: in vitro effect of its association with Amphotericin B.

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Journal:  Antimicrob Agents Chemother       Date:  2014-08-11       Impact factor: 5.191

2.  Antimicrobial activity of euplotin C, the sesquiterpene taxonomic marker from the marine ciliate Euplotes crassus.

Authors:  Dianella Savoia; Claudio Avanzini; Tiziano Allice; Emanuela Callone; Graziano Guella; Fernando Dini
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

3.  Leishmanicidal Effect of Synthetic trans-Resveratrol Analogs.

Authors:  Carlos Luan Alves Passos; Christian Ferreira; Deivid Costa Soares; Elvira Maria Saraiva
Journal:  PLoS One       Date:  2015-10-30       Impact factor: 3.240

4.  Iboga Inspired N-Indolylethyl-Substituted Isoquinuclidines as a Bioactive Scaffold: Chemoenzymatic Synthesis and Characterization as GDNF Releasers and Antitrypanosoma Agents.

Authors:  Mariana Pazos; Estefania Dibello; Juan Manuel Mesa; Dalibor Sames; Marcelo Alberto Comini; Gustavo Seoane; Ignacio Carrera
Journal:  Molecules       Date:  2022-01-27       Impact factor: 4.411
  4 in total

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