Literature DB >> 12069816

Trans-regulation of epidermal growth factor receptor by lysophosphatidic acid and G protein-coupled receptors.

Jie Wu1, Jess M Cunnick.   

Abstract

Lysophosphatidic acid (LPA) is known to induce protein tyrosine phosphorylation and has growth factor-like effects. In the last several years, the epidermal growth factor (EGF) receptor has been recognized as a protein tyrosine kinase that plays a central role in mediating LPA-induced tyrosine phosphorylation and Erk MAP kinase activation. In this article, we review recent progress in the study of trans-regulation of EGF receptor by LPA and G protein-coupled receptors (GPCR) and discuss the gap in our knowledge of the mechanism by which LPA induces EGF receptor activation.

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Year:  2002        PMID： 12069816     DOI： 10.1016/s1388-1981(02)00143-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor.

Authors:  Ke-Ping Xu; Jia Yin; Fu-Shin X Yu
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-02       Impact factor: 4.799

2.  Gq protein-induced apoptosis is mediated by AKT kinase inhibition that leads to protein kinase C-induced c-Jun N-terminal kinase activation.

Authors:  Ido Ben-Ami; Zhong Yao; Zvi Naor; Rony Seger
Journal:  J Biol Chem       Date:  2011-07-13       Impact factor: 5.157

3.  Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts.

Authors:  Tetsuya Shiomi; Francis Boudreault; Nurcicek Padem; Shigeki Higashiyama; Jeffrey M Drazen; Daniel J Tschumperlin
Journal:  Wound Repair Regen       Date:  2011 Mar-Apr       Impact factor: 3.617

4.  Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5.

Authors:  Huanchun Zhang; Agnieszka Bialkowska; Raluca Rusovici; Sengthong Chanchevalap; Hyunsuk Shim; Jonathan P Katz; Vincent W Yang; C Chris Yun
Journal:  J Biol Chem       Date:  2007-04-12       Impact factor: 5.157

5.  Splenic vasculopathy in portal hypertension patients.

Authors:  Tao Li; Ji-Yuan Ni; Yan-Wu Qi; Hai-Yang Li; Tong Zhang; Zhen Yang
Journal:  World J Gastroenterol       Date:  2006-05-07       Impact factor: 5.742

6.  Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells.

Authors:  Regina A Oyesanya; Zendra P Lee; Jinhua Wu; Jing Chen; Yuanda Song; Abir Mukherjee; Paul Dent; Tomasz Kordula; Huiping Zhou; Xianjun Fang
Journal:  FASEB J       Date:  2008-03-24       Impact factor: 5.191

7.  P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion.

Authors:  Mike Lee; Sungwon Choi; Gunnel Halldén; Sek Jin Yo; Denise Schichnes; Gregory W Aponte
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2009-08-13       Impact factor: 4.052

8.  GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch.

Authors:  Guy Nadel; Zhong Yao; Ehud Wainstein; Izel Cohen; Ido Ben-Ami; Amir Schajnovitz; Galia Maik-Rachline; Zvi Naor; Benjamin A Horwitz; Rony Seger
Journal:  Cell Commun Signal       Date:  2022-01-08       Impact factor: 5.712

9.  Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid.

Authors:  Regina A Oyesanya; Susie Greenbaum; David Dang; Zendra Lee; Abir Mukherjee; Jinhua Wu; Paul Dent; Xianjun Fang
Journal:  Mol Cancer       Date:  2010-01-14       Impact factor: 27.401
  9 in total

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