RATIONALE AND OBJECTIVES: To compare the effects of two iodinated contrast media, iodixanol and ioxaglate, on outer medullary blood flow (MBF) and oxygen tension (MPO(2)) in the dog kidney. METHODS: Iodixanol and ioxaglate were injected selectively into the renal artery (320 mgI/kg) of anesthetized Beagle dogs. MBF and MPO(2) were measured with a laser-Doppler probe and an oxygen-sensing microelectrode implanted in the outer medulla. Urine samples were collected for viscosity and osmolality measurements. RESULTS: Both contrast media produced a moderate decrease in MBF and MPO(2). The hypoperfusion and hypoxia lasted significantly longer with iodixanol than with ioxaglate. Theophylline, an adenosine receptor antagonist, partially prevented iodixanol-induced hypoxia. Urine viscosity was dramatically increased by iodixanol but not by ioxaglate. Urine osmolality did not differ significantly between groups. CONCLUSION: Iodixanol produced a more sustained medullary hypoxia than ioxaglate when injected selectively into the dog renal artery. This may lead to hypoxic cellular damage and subsequent impairment of kidney functions.
RATIONALE AND OBJECTIVES: To compare the effects of two iodinated contrast media, iodixanol and ioxaglate, on outer medullary blood flow (MBF) and oxygen tension (MPO(2)) in the dog kidney. METHODS:Iodixanol and ioxaglate were injected selectively into the renal artery (320 mgI/kg) of anesthetized Beagle dogs. MBF and MPO(2) were measured with a laser-Doppler probe and an oxygen-sensing microelectrode implanted in the outer medulla. Urine samples were collected for viscosity and osmolality measurements. RESULTS: Both contrast media produced a moderate decrease in MBF and MPO(2). The hypoperfusion and hypoxia lasted significantly longer with iodixanol than with ioxaglate. Theophylline, an adenosine receptor antagonist, partially prevented iodixanol-induced hypoxia. Urine viscosity was dramatically increased by iodixanol but not by ioxaglate. Urine osmolality did not differ significantly between groups. CONCLUSION:Iodixanol produced a more sustained medullary hypoxia than ioxaglate when injected selectively into the dog renal artery. This may lead to hypoxic cellular damage and subsequent impairment of kidney functions.
Authors: V O Gomes; C E Poli de Figueredo; P Caramori; R Lasevitch; L C Bodanese; A Araújo; A P Röedel; A P Caramori; F S Brito; H G Bezerra; P Nery; A Brizolara Journal: Heart Date: 2005-06 Impact factor: 5.994
Authors: S Bhandari; A Seth; K K Sethi; S Tyagi; R Gupta; S C Tiwari; S Mehrotra; Ashok Seth; Santanu Guha; P K Deb; Arup Dasbiswas; P P Mohanan; K Venugopal; Nakul Sinha; Brian Pinto; Amal Banerjee; G Sengottuvelu; Roxana Mehran; Peter Mc Collough Journal: Indian Heart J Date: 2012-11-17
Authors: Shruti Kanakia; Jimmy D Toussaint; Sayan Mullick Chowdhury; Gaurav Lalwani; Tanuf Tembulkar; Terry Button; Kenneth R Shroyer; William Moore; Balaji Sitharaman Journal: Int J Nanomedicine Date: 2013-08-05