Literature DB >> 12067725

Estrogens prevent calcium-induced release of cytochrome c from heart mitochondria.

Ramune Morkuniene1, Aiste Jekabsone, Vilmante Borutaite.   

Abstract

We investigated the effect of estrogens on heart mitochondrial functions and whether estrogens can prevent calcium-induced release of cytochrome c from mitochondria. 10 nM-10 microM 17beta-estradiol or 4-hydroxytamoxifen did not affect mitochondrial respiration rate and membrane potential in state 3 and state 4. Higher concentrations of both agents decreased state 3 respiration rate and membrane potential. 100 nM 17beta-estradiol and 4-hydroxytamoxifen blocked high calcium-induced cytochrome c release from mitochondria but not mitochondrial swelling. Thus, at physiological concentrations estrogens do not affect mitochondrial respiratory functions but protect heart mitochondria from high calcium-induced release of cytochrome c.

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Year:  2002        PMID： 12067725     DOI： 10.1016/s0014-5793(02)02820-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

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Review 10.  Reciprocality Between Estrogen Biology and Calcium Signaling in the Cardiovascular System.

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Journal:  Front Endocrinol (Lausanne)       Date:  2020-09-29       Impact factor: 5.555
  10 in total

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