Genes, mitochondria and aging in filamentous fungi.

Fungi are eukaryotic microorganisms studied in various areas of general and applied biology. A few species were among the first systems in which specific aspects of aging were addressed experimentally. Various factors, both environmental and genetic, were found to affect lifespan and aging. Mitochondrial pathways play a paramount role. Since mitochondria are semiautonomous organelles and depend on both nuclear as well as mitochondrial genes, mitochondrial-nuclear interactions are of major relevance. As a main generator of reactive oxygen species (ROS), mitochondria are prone to molecular damage. However, cells can cope with the negative effects of ROS utilizing different scavenging systems and, once defects became manifested, by repair of damaged molecules. Both, lowering ROS generation and increasing mitochondrial "caretaker" systems bear great potential to interfere with natural aging processes.