Risk assessment of dioxin contamination in human food.

Dioxins are highly toxic by-products of incineration processes and of production of chloro-organic chemicals. Accidental poisonings have occurred repeatedly. The main human exposure is via the dietary route. Species comparisons of toxic effects on the basis of ingested doses are not possible because of the highly differing toxicokinetics between humans and experimental animals. On the basis of internal doses or body burdens acute toxic and tumorigenic responses are observed at similar levels in humans and rats. PCB/PCDD/F contamination at levels which have been reported of marketed chicken meat and eggs in 1999 in Belgium may have increased body burdens by approximately 10%. However, it is estimated that a several hundred-fold higher uptake would be necessary to reach body burdens leading to overt toxicity in normal human subjects.