| Literature DB >> 12067561 |
Dean A Wacker1, Joseph B Santella, Daniel S Gardner, Jeffrey G Varnes, Melissa Estrella, George V DeLucca, Soo S Ko, Keiichi Tanabe, Paul S Watson, Patricia K Welch, Maryanne Covington, Nicole C Stowell, Eric A Wadman, Paul Davies, Kimberly A Solomon, Robert C Newton, George L Trainor, Steven M Friedman, Carl P Decicco, John V Duncia.
Abstract
CCR3 antagonist leads with IC(50) values in the microM range were converted into low nM binding compounds that displayed in vitro inhibition of human eosinophil chemotaxis induced by human eotaxin. In particular, 4-benzylpiperidin-1-yl-n-propylureas and erythro-3-(4-benzyl-2-(alpha-hydroxyalkyl)piperidin-1-yl)-n-propylureas (obtained via Beak reaction of N-BOC-4-benzylpiperidine) exhibited single digit nanomolar IC(50) values for CCR3.Entities:
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Year: 2002 PMID： 12067561 DOI： 10.1016/s0960-894x(02)00206-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823