Literature DB >> 12067560

The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection.

Piyasena Hewawasam1, Wenhong Fan, Jay Knipe, Sandra L Moon, Christopher G Boissard, Valentin K Gribkoff, John E Starrett.   

Abstract

A series of 4-aryl-3-aminoquinoline-2-one derivatives was synthesized and evaluated as activators of the cloned maxi-K channel mSlo (hSlo) expressed in Xenopus laevis oocytes using electrophysiological methods. A brain penetrable activator of maxi-K channels was identified and shown to be significantly active in the MCAO model of stroke.

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Year:  2002        PMID： 12067560     DOI： 10.1016/s0960-894x(02)00240-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Structure-activity relationship study of copper(II) complexes with 2-oxo-1,2-dihydroquinoline-3-carbaldehyde (4'-methylbenzoyl) hydrazone: synthesis, structures, DNA and protein interaction studies, antioxidative and cytotoxic activity.

Authors:  Duraisamy Senthil Raja; Nattamai S P Bhuvanesh; Karuppannan Natarajan
Journal:  J Biol Inorg Chem       Date:  2011-09-20       Impact factor: 3.358

2.  Computer Aided Prediction of Biological Activity Spectra: Study of Correlation between Predicted and Observed Activities for Coumarin-4-Acetic Acids.

Authors:  M Basanagouda; V B Jadhav; M V Kulkarni; R Nagendra Rao
Journal:  Indian J Pharm Sci       Date:  2011-01       Impact factor: 0.975

3.  Synthesis of quinolin-2-one alkaloid derivatives and their inhibitory activities against HIV-1 reverse transcriptase.

Authors:  Pi Cheng; Qiong Gu; Wei Liu; Jian-Feng Zou; Yang-Yong Ou; Zhong-Yong Luo; Jian-Guo Zeng
Journal:  Molecules       Date:  2011-09-07       Impact factor: 4.411

4.  Convergent Synthesis of N,S-bis Glycosylquinolin-2-ones via a Pd-G3-XantPhos Precatalyst Catalysis.

Authors:  Wafa Redjdal; Nada Ibrahim; Belkacem Benmerad; Mouad Alami; Samir Messaoudi
Journal:  Molecules       Date:  2018-02-26       Impact factor: 4.411

5.  Camphorsulfonic Acid-Mediated One-Pot Tandem Consecutive via the Ugi Four-Component Reaction for the Synthesis of Functionalized Indole and 2-Quinolone Derivatives by Switching Solvents.

Authors:  Sivan Perumal Murugan; Hong-Jie Zhong; Chih-Yu Wu; Hao-Wei Pan; Chinpiao Chen; Gene-Hsian Lee
Journal:  ACS Omega       Date:  2022-02-10
  5 in total

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