| Literature DB >> 12067554 |
Jason M Elliott1, Jose L Castro, Gary G Chicchi, Laura C Cooper, Kevin Dinnell, Gregory J Hollingworth, Mark P Ridgill, Wayne Rycroft, Marc M Kurtz, Duncan E Shaw, Christopher J Swain, Kwei-Lan Tsao, Lihu Yang.
Abstract
A series of novel 4,4-disubstituted cyclohexylamine based NK(1) antagonists is described. The effect of changes to the C(1)-C(4) relative stereochemistry on the cyclohexane ring and replacements for the flexible linker are discussed, leading to the identification of compounds with high affinity and good in vivo duration of action.Entities:
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Year: 2002 PMID： 12067554 DOI： 10.1016/s0960-894x(02)00249-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823