| Literature DB >> 12067234 |
Felix Schlachetzki1, Chunni Zhu, William M Pardridge.
Abstract
The blood-brain barrier (BBB) restricts transport of immunoglobulin G (IgG) in the blood to brain direction. However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the characteristics of an Fc receptor (FcR), but there is no molecular information on the putative BBB FcR. The present study uses confocal microscopy and an antibody to the rat neonatal FcR (FcRn), and demonstrates the expression of the FcRn at the brain microvasculature and choroid plexus epithelium. Co-localization with the Glut1 glucose transporter indicates the brain microvascular FcRn is expressed in the capillary endothelium. The capillary endothelial FcRn may mediate the 'reverse transcytosis' of IgG in the brain to blood direction.Entities:
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Year: 2002 PMID： 12067234 DOI： 10.1046/j.1471-4159.2002.00840.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372