| Literature DB >> 12067100 |
Toshihiro Miura1, Ko Furuta, Akiyo Yasuda, Naoki Iwamoto, Motoshi Kato, Eriko Ishihara, Torao Ishida, Keiichiro Tanigawa.
Abstract
In the past, nitobegiku (the herb of Tithonia diversifolia (Hemsl) A. Gray) has been used as a medicinal plant for diabetes. Antidiabetic effect of the water extract of Nitobegiku (NG) was investigated in KK-Ay-mice--one of the animal models of type 2 diabetes. NG (1,500 mg/kg body weight) reduced the blood glucose of KK-Ay mice from 509 +/- 22 mg/dl to 340 +/- 14 mg/dl (p < 0.001) and also lowered the plasma insulin (p < 0.05) 7 hours after single oral administration. No change in blood glucose of NG-treated normal mice (ddY) was seen. These results support that NG improve glucose metabolism by reducing insulin resistance. Therefore, NG may be useful for treatment of type 2 diabetes.Entities:
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Year: 2002 PMID： 12067100 DOI： 10.1142/S0192415X02000090
Source DB: PubMed Journal: Am J Chin Med ISSN： 0192-415X Impact factor: 4.667