Literature DB >> 12065544

Fibrinogen binding to intercellular adhesion molecule 1: implications for Plasmodium falciparum adhesion.

Carolyn Gray1, Alister Craig.   

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions.

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Year:  2002        PMID： 12065544      PMCID： PMC128049          DOI： 10.1128/IAI.70.7.3962-3964.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


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Authors:  A R Berendt; D L Simmons; J Tansey; C I Newbold; K Marsh
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