Literature DB >> 12065417

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.

Berthold Göttgens1, Aristotelis Nastos, Sarah Kinston, Sandie Piltz, Eric C M Delabesse, Maureen Stanley, Maria-Jose Sanchez, Aldo Ciau-Uitz, Roger Patient, Anthony R Green.   

Abstract

Stem cells are a central feature of metazoan biology. Haematopoietic stem cells (HSCs) represent the best-characterized example of this phenomenon, but the molecular mechanisms responsible for their formation remain obscure. The stem cell leukaemia (SCL) gene encodes a basic helix-loop-helix (bHLH) transcription factor with an essential role in specifying HSCs. Here we have addressed the transcriptional hierarchy responsible for HSC formation by characterizing an SCL 3' enhancer that targets expression to HSCs and endothelium and their bipotential precursors, the haemangioblast. We have identified three critical motifs, which are essential for enhancer function and bind GATA-2, Fli-1 and Elf-1 in vivo. Our results suggest that these transcription factors are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12065417      PMCID： PMC126046          DOI： 10.1093/emboj/cdf286

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  103 in total

1.  Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.

Authors:  K Giese; C Kingsley; J R Kirshner; R Grosschedl
Journal:  Genes Dev       Date:  1995-04-15       Impact factor: 11.361

2.  A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.

Authors:  J Ellis; K C Tan-Un; A Harper; D Michalovich; N Yannoutsos; S Philipsen; F Grosveld
Journal:  EMBO J       Date:  1996-02-01       Impact factor: 11.598

3.  Potential intraembryonic hemogenic sites at pre-liver stages in the mouse.

Authors:  J A Garcia-Porrero; I E Godin; F Dieterlen-Lièvre
Journal:  Anat Embryol (Berl)       Date:  1995-11

4.  Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.

Authors:  S John; R B Reeves; J X Lin; R Child; J M Leiden; C B Thompson; W J Leonard
Journal:  Mol Cell Biol       Date:  1995-03       Impact factor: 4.272

5.  Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3.

Authors:  M Towatari; G E May; R Marais; G R Perkins; C J Marshall; S Cowley; T Enver
Journal:  J Biol Chem       Date:  1995-02-24       Impact factor: 5.157

6.  AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Authors:  T Okuda; J van Deursen; S W Hiebert; G Grosveld; J R Downing
Journal:  Cell       Date:  1996-01-26       Impact factor: 41.582

7.  Lineage-restricted regulation of the murine SCL/TAL-1 promoter.

Authors:  E O Bockamp; F McLaughlin; A M Murrell; B Göttgens; L Robb; C G Begley; A R Green
Journal:  Blood       Date:  1995-08-15       Impact factor: 22.113

Review 8.  Mouse embryonic hematopoiesis.

Authors:  E Dzierzak; A Medvinsky
Journal:  Trends Genet       Date:  1995-09       Impact factor: 11.639

9.  Targeting gene expression to haemopoietic stem cells: a chromatin-dependent upstream element mediates cell type-specific expression of the stem cell antigen CD34.

Authors:  G May; T Enver
Journal:  EMBO J       Date:  1995-02-01       Impact factor: 11.598

10.  Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages.

Authors:  D Y Stainier; B M Weinstein; H W Detrich; L I Zon; M C Fishman
Journal:  Development       Date:  1995-10       Impact factor: 6.868
View more
  84 in total

1.  Developmentally regulated recruitment of transcription factors and chromatin modification activities to chicken lysozyme cis-regulatory elements in vivo.

Authors:  Pascal Lefevre; Svitlana Melnik; Nicola Wilson; Arthur D Riggs; Constanze Bonifer
Journal:  Mol Cell Biol       Date:  2003-06       Impact factor: 4.272

2.  Analysis of multiple genomic sequence alignments: a web resource, online tools, and lessons learned from analysis of mammalian SCL loci.

Authors:  Michael A Chapman; Ian J Donaldson; James Gilbert; Darren Grafham; Jane Rogers; Anthony R Green; Berthold Göttgens
Journal:  Genome Res       Date:  2004-01-12       Impact factor: 9.043

3.  The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1.

Authors:  Berthold Göttgens; Cyril Broccardo; Maria-Jose Sanchez; Sophie Deveaux; George Murphy; Joachim R Göthert; Ekaterini Kotsopoulou; Sarah Kinston; Liz Delaney; Sandie Piltz; Linda M Barton; Kathy Knezevic; Wendy N Erber; C Glenn Begley; Jonathan Frampton; Anthony R Green
Journal:  Mol Cell Biol       Date:  2004-03       Impact factor: 4.272

4.  cis-Regulatory remodeling of the SCL locus during vertebrate evolution.

Authors:  Berthold Göttgens; Rita Ferreira; Maria-José Sanchez; Shoko Ishibashi; Juan Li; Dominik Spensberger; Pascal Lefevre; Katrin Ottersbach; Michael Chapman; Sarah Kinston; Kathy Knezevic; Maarten Hoogenkamp; George A Follows; Constanze Bonifer; Enrique Amaya; Anthony R Green
Journal:  Mol Cell Biol       Date:  2010-10-18       Impact factor: 4.272

5.  Effect of endoglin overexpression during embryoid body development.

Authors:  June Baik; Luciene Borges; Alessandro Magli; Tayaramma Thatava; Rita C R Perlingeiro
Journal:  Exp Hematol       Date:  2012-06-19       Impact factor: 3.084

6.  GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).

Authors:  Li Wang; Yi Jia; Heather Rogers; Yun-Ping Wu; Suming Huang; Constance Tom Noguchi
Journal:  J Biol Chem       Date:  2012-07-07       Impact factor: 5.157

7.  Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells.

Authors:  LiQi Li; Raja Jothi; Kairong Cui; Jan Y Lee; Tsadok Cohen; Marat Gorivodsky; Itai Tzchori; Yangu Zhao; Sandra M Hayes; Emery H Bresnick; Keji Zhao; Heiner Westphal; Paul E Love
Journal:  Nat Immunol       Date:  2010-12-26       Impact factor: 25.606

8.  Discovery of functional noncoding elements by digital analysis of chromatin structure.

Authors:  Peter J Sabo; Michael Hawrylycz; James C Wallace; Richard Humbert; Man Yu; Anthony Shafer; Janelle Kawamoto; Robert Hall; Joshua Mack; Michael O Dorschner; Michael McArthur; John A Stamatoyannopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-18       Impact factor: 11.205

9.  Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.

Authors:  Xiaozhong Shi; Jai Richard; Katie M Zirbes; Wuming Gong; Gufa Lin; Michael Kyba; Jamie A Thomson; Naoko Koyano-Nakagawa; Daniel J Garry
Journal:  Dev Biol       Date:  2014-02-26       Impact factor: 3.582

10.  Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors.

Authors:  Sarah De Val; Neil C Chi; Stryder M Meadows; Simon Minovitsky; Joshua P Anderson; Ian S Harris; Melissa L Ehlers; Pooja Agarwal; Axel Visel; Shan-Mei Xu; Len A Pennacchio; Inna Dubchak; Paul A Krieg; Didier Y R Stainier; Brian L Black
Journal:  Cell       Date:  2008-12-12       Impact factor: 41.582
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.