| Literature DB >> 12064799 |
Stephan Miehlke1, Jun Yu, Matthias Ebert, Daniel Szokodi, Michael Vieth, Eberhard Kuhlisch, Rene Buchcik, Wolfgang Schimmin, Ursula Wehrmann, Peter Malfertheiner, Gerhard Ehninger, Ekkehard Bayerdörffer, Manfred Stolte.
Abstract
The aim of this study was to investigate the expression of D-type cyclins and cyclin E in gastric cancer patients (N = 34), in healthy first-degree relatives of gastric cancer patients (N = 29), and in control subjects (N = 18). Expression of cyclins D1, D2, D3, and E was determined by RT-PCR. Localization of cyclin expression was determined by immunohistochemistry. Expression of cyclins D2, D3, and E was more frequently detected in tumor tissue compared with tumor-free gastric mucosa (P < 0.05) and was associated with the presence of intestinal metaplasia. In contrast, cyclin D1 was frequently expressed in both tumor- and tumor-free tissue. Cyclin D3 expression was more frequently detected in the antrum mucosa of first-degree relatives compared to controls (P < 0.01) and was associated with the presence of Helicobacter pylori. Our data suggest that deregulation of G1 phase cyclins may play a role in gastric carcinogenesis, and may point to the presence of molecular alterations in individuals at an increased risk for gastric cancer.Entities:
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Year: 2002 PMID： 12064799 DOI： 10.1023/a:1015358127751
Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199