| Literature DB >> 12064726 |
Inga Köhler1, Kristina Jenett-Siems, Karsten Siems, Marco Antonio Hernández, Ricardo A Ibarra, Walter G Berendsohn, Ulrich Bienzle, Eckart Eich.
Abstract
In vitro antiplasmodial activities of extracts from Albizia saman, Fabaceae, Calea tenuifolia (C. zacatechichi), Asteraceae, Hymenaea courbaril, Fabaceae, Jatropha curcas, Euphorbiaceae, Momordica charantia, Cucurbitaceae, and Moringa oleifera, Moringaceae were evaluated. From the lipophilic extract of C tenuifolia five active flavones were obtained. 4',5-Dihydroxy-7-methoxyflavone [genkwanin] and 5-hydroxy-4',7-dimethoxyflavone [apigenin 4',7-dimethylether] exhibited the strongest antiplasmodial activity against a chloroquine-sensitive strain (poW) and a chloroquine-resistant strain (Dd2) of Plasmodium falciparum [IC50 values: 17.1-28.5 microM). Furthermore octadeca-9,12-dienoic acid [linoleic acid] [IC50] values of 21.8 microM (poW) and 31.1 microM (Dd2)] and octadeca-9,12,15-trienoic acid (alpha-linolenic acid) were isolated.Entities:
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Year: 2002 PMID： 12064726 DOI： 10.1515/znc-2002-3-413
Source DB: PubMed Journal: Z Naturforsch C J Biosci ISSN： 0341-0382