Literature DB >> 12064005

Laparoscopic splenectomy for portal hypertension.

Makoto Hashizume1, Morimasa Tomikawa, Tomohiko Akahoshi, Kazuo Tanoue, Norikazu Gotoh, Kozo Konishi, Keishi Okita, Norifumi Tsutsumi, Rinshun Shimabukuro, Shohei Yamaguchi, Keizo Sugimachi.   

Abstract

BACKGROUND/AIMS: Laparoscopic splenectomy is now increasingly being performed. However, controversy remains regarding the effectiveness of a laparoscopic splenectomy for patients with portal hypertension.
METHODOLOGY: Seventy-three patients with portal hypertension who underwent a laparoscopic splenectomy from February 1992 until October 2000 were reviewed and the effectiveness of the procedures for portal hypertension was evaluated. Forty-two patients had esophagogastric varices and twenty had a concomitant hepatocellular carcinoma. The indications for surgery were bleeding tendency due to thrombocytopenia (n = 40), difficulty in receiving treatment for hepatocellular carcinoma due to thrombocytopenia (n = 18), and sclerotherapy-resistant esophagogastric varices (n = 15).
RESULTS: A laparoscopic splenectomy was successfully performed in all the patients. The rate of conversion to conventional open surgery was 9.6% (7/73). The mean operative time was 210.1 +/- 101.9 minutes, and the estimated blood loss was 374.7 +/- 352.4 mL. There were no cases of mortality, and morbidity was encountered in 11.0% of patients. The increase in the platelet count correlated significantly to the spleen weight (P < 0.001). The platelet count had been maintained at over 10 x 10(4)/mm3 for over three years. Eighteen patients with hepatocellular carcinoma successfully underwent treatment for hepatocellular carcinoma after surgery and no recurrence of esophagogastric varices was encountered.
CONCLUSIONS: A laparoscopic splenectomy resulted in the successful secondary treatment of hepatocellular carcinoma and esophagogastric varices. Portal hypertension was not a contraindication. A laparoscopic approach is therefore the procedure of choice for a splenectomy in portal hypertension.

Entities:  

Mesh:

Year:  2002        PMID: 12064005

Source DB:  PubMed          Journal:  Hepatogastroenterology        ISSN: 0172-6390


  19 in total

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7.  Laparoscopic splenectomy reverses thrombocytopenia in patients with hepatitis C cirrhosis and portal hypertension.

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Review 9.  Management of thrombocytopenia due to liver cirrhosis: a review.

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Review 10.  Management of thrombocytopenia in advanced liver disease.

Authors:  V G R Gangireddy; P C Kanneganti; S Sridhar; S Talla; T Coleman
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