PURPOSE: To determine the effects of aging on the first and second-order kernels of the multifocal electroretinogram (ERG). METHODS: Multifocal ERGs were recorded from 52 healthy subjects (52 eyes) (0 >or= refractive error >or= -3.0 diopter). The ages of the subjects ranged from 12-76 years with a mean (+/-SD) of 44.0 +/- 20.2 years. The Visual Evoked Response Imaging System was used. The effects of aging on the response densities and on the implicit times of the first positive wave (P1) of the first-order kernel, and of the second and third positive waves (P2 and P3) of the second-order kernel were analyzed for the different age groups. RESULTS: The response densities of the first-order kernel P1 and second-order kernel P2 waves decreased significantly, and the implicit times of the second-order kernel P2, and P3 were significantly prolonged (P <.05) in subjects over 50 years of age. CONCLUSION: The results suggest that the age of the subject should be considered when evaluating retinal function using multifocal ERGs in basic and clinical studies.
PURPOSE: To determine the effects of aging on the first and second-order kernels of the multifocal electroretinogram (ERG). METHODS: Multifocal ERGs were recorded from 52 healthy subjects (52 eyes) (0 >or= refractive error >or= -3.0 diopter). The ages of the subjects ranged from 12-76 years with a mean (+/-SD) of 44.0 +/- 20.2 years. The Visual Evoked Response Imaging System was used. The effects of aging on the response densities and on the implicit times of the first positive wave (P1) of the first-order kernel, and of the second and third positive waves (P2 and P3) of the second-order kernel were analyzed for the different age groups. RESULTS: The response densities of the first-order kernel P1 and second-order kernel P2 waves decreased significantly, and the implicit times of the second-order kernel P2, and P3 were significantly prolonged (P <.05) in subjects over 50 years of age. CONCLUSION: The results suggest that the age of the subject should be considered when evaluating retinal function using multifocal ERGs in basic and clinical studies.
Authors: Glen Y Ozawa; Marcus A Bearse; Wendy W Harrison; Kevin W Bronson-Castain; Marilyn E Schneck; Shirin Barez; Anthony J Adams Journal: Optom Vis Sci Date: 2014-06 Impact factor: 1.973
Authors: Livia M Brandao; Anna A Ledolter; Matthias Monhart; Andreas Schötzau; Anja M Palmowski-Wolfe Journal: Graefes Arch Clin Exp Ophthalmol Date: 2017-08-04 Impact factor: 3.117