Literature DB >> 12062169

Centrosomes and cancer: lessons from a TACC.

Jordan W Raff1.   

Abstract

The recent discovery that many cancer cells have centrosomal abnormalities suggests a link between centrosomes and cancer. Members of the transforming acidic coiled-coil (TACC) family of proteins have been implicated in cancer and are concentrated at centrosomes, where they regulate microtubule stability. I discuss a model of how the TACC proteins might contribute to cancer. This model predicts that defects in TACC function can make important contributions to the development of cancer but are unlikely to be the primary cause of cancer. The model might also apply to several other centrosomal proteins that have been linked to cancer.

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Year:  2002        PMID： 12062169     DOI： 10.1016/s0962-8924(02)02268-7

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  35 in total

1.  Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation.

Authors:  Masamitsu Sato; Leah Vardy; Miguel Angel Garcia; Nirada Koonrugsa; Takashi Toda
Journal:  Mol Biol Cell       Date:  2004-01-23       Impact factor: 4.138

2.  The fission yeast transforming acidic coiled coil-related protein Mia1p/Alp7p is required for formation and maintenance of persistent microtubule-organizing centers at the nuclear envelope.

Authors:  Liling Zheng; Cindi Schwartz; Liangmeng Wee; Snezhana Oliferenko
Journal:  Mol Biol Cell       Date:  2006-02-15       Impact factor: 4.138

3.  The XMAP215 homologue Stu2 at yeast spindle pole bodies regulates microtubule dynamics and anchorage.

Authors:  Takeo Usui; Hiromi Maekawa; Gislene Pereira; Elmar Schiebel
Journal:  EMBO J       Date:  2003-09-15       Impact factor: 11.598

4.  Multiple centrosomes: together they stand, divided they fall.

Authors:  Fanni Gergely; Renata Basto
Journal:  Genes Dev       Date:  2008-09-01       Impact factor: 11.361

5.  TACC3 protein regulates microtubule nucleation by affecting γ-tubulin ring complexes.

Authors:  Puja Singh; Geethu Emily Thomas; Koyikulangara K Gireesh; Tapas K Manna
Journal:  J Biol Chem       Date:  2014-09-22       Impact factor: 5.157

6.  Elevated Expression of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) Is Associated With a Poor Prognosis in Osteosarcoma.

Authors:  Kotaro Matsuda; Hiroaki Miyoshi; Koji Hiraoka; Tetsuya Hamada; Kazutaka Nakashima; Naoto Shiba; Koichi Ohshima
Journal:  Clin Orthop Relat Res       Date:  2018-09       Impact factor: 4.176

7.  Cigarette smoke exposure enhances transforming acidic coiled-coil-containing protein 2 turnover and thereby promotes emphysema.

Authors:  Rama K Mallampalli; Xiuying Li; Jun-Ho Jang; Tomasz Kaminski; Aki Hoji; Tiffany Coon; Divay Chandra; Starr Welty; Yaqun Teng; John Sembrat; Mauricio Rojas; Yutong Zhao; Robert Lafyatis; Chunbin Zou; Frank Sciurba; Prithu Sundd; Li Lan; Toru Nyunoya
Journal:  JCI Insight       Date:  2020-01-30

8.  The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly.

Authors:  Lori L O'Brien; Alison J Albee; Lingling Liu; Wei Tao; Pawel Dobrzyn; Sofia B Lizarraga; Christiane Wiese
Journal:  Mol Biol Cell       Date:  2005-03-23       Impact factor: 4.138

9.  Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamics.

Authors:  Chong J Park; Jung-Eun Park; Tatiana S Karpova; Nak-Kyun Soung; Li-Rong Yu; Sukgil Song; Kyung H Lee; Xue Xia; Eugene Kang; Ilknur Dabanoglu; Doo-Yi Oh; James Y Zhang; Young Hwi Kang; Stephen Wincovitch; Tim C Huffaker; Timothy D Veenstra; James G McNally; Kyung S Lee
Journal:  Eukaryot Cell       Date:  2008-01-04

10.  The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.

Authors:  Romain Guyot; Séverine Vincent; Julie Bertin; Jacques Samarut; Patrick Ravel-Chapuis
Journal:  BMC Mol Biol       Date:  2010-01-15       Impact factor: 2.946
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