Literature DB >> 12062100

Cid13 is a cytoplasmic poly(A) polymerase that regulates ribonucleotide reductase mRNA.

Shigeaki Saitoh1, Andrei Chabes, W Hayes McDonald, Lars Thelander, John R Yates, Paul Russell.   

Abstract

Fission yeast Cid13 and budding yeast Trf4/5 are members of a newly identified nucleotidyltransferase family conserved from yeast to man. Trf4/5 are thought to be essential DNA polymerases. We report that Cid13 is a poly(A) polymerase. Unlike conventional poly(A) polymerases, which act in the nucleus and indiscriminately polyadenylate all mRNA, Cid13 is a cytoplasmic enzyme that specifically targets suc22 mRNA that encodes a subunit of ribonucleotide reductase (RNR). cid13 mutants have reduced dNTP pools and are sensitive to hydroxyurea, an RNR inhibitor. We propose that Cid13 defines a cytoplasmic form of poly(A) polymerase important for DNA replication and genome maintenance.

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Year:  2002        PMID： 12062100     DOI： 10.1016/s0092-8674(02)00753-5

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  59 in total

1.  Purifying mRNAs with a high-affinity eIF4E mutant identifies the short 3' poly(A) end phenotype.

Authors:  Youkyung Hwang Choi; Curt H Hagedorn
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2.  S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion.

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Journal:  Mol Biol Cell       Date:  2004-01-23       Impact factor: 4.138

3.  Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase.

Authors:  Rafal Tomecki; Aleksandra Dmochowska; Kamil Gewartowski; Andrzej Dziembowski; Piotr P Stepien
Journal:  Nucleic Acids Res       Date:  2004-11-16       Impact factor: 16.971

4.  Identification of the major spliceosomal RNAs in Dictyostelium discoideum reveals developmentally regulated U2 variants and polyadenylated snRNAs.

Authors:  Andrea Hinas; Pontus Larsson; Lotta Avesson; Leif A Kirsebom; Anders Virtanen; Fredrik Söderbom
Journal:  Eukaryot Cell       Date:  2006-06

5.  Arabidopsis ribonucleotide reductases are critical for cell cycle progression, DNA damage repair, and plant development.

Authors:  Chunxin Wang; Zhongchi Liu
Journal:  Plant Cell       Date:  2006-01-06       Impact factor: 11.277

6.  Autoregulation of GLD-2 cytoplasmic poly(A) polymerase.

Authors:  Labib Rouhana; Marvin Wickens
Journal:  RNA       Date:  2006-12-12       Impact factor: 4.942

7.  Fission yeast Cid12 has dual functions in chromosome segregation and checkpoint control.

Authors:  Thein Z Win; Abigail L Stevenson; Shao-Win Wang
Journal:  Mol Cell Biol       Date:  2006-06       Impact factor: 4.272

8.  Regulation of poly(A) polymerase by 14-3-3epsilon.

Authors:  Hana Kim; June Hyung Lee; Younghoon Lee
Journal:  EMBO J       Date:  2003-10-01       Impact factor: 11.598

9.  Intrinsic 5'-deoxyribose-5-phosphate lyase activity in Saccharomyces cerevisiae Trf4 protein with a possible role in base excision DNA repair.

Authors:  Lionel Gellon; Dena R Carson; Jonathan P Carson; Bruce Demple
Journal:  DNA Repair (Amst)       Date:  2007-11-05

10.  Rice virescent3 and stripe1 encoding the large and small subunits of ribonucleotide reductase are required for chloroplast biogenesis during early leaf development.

Authors:  Soo-Cheul Yoo; Sung-Hwan Cho; Hiroki Sugimoto; Jinjie Li; Kensuke Kusumi; Hee-Jong Koh; Koh Iba; Nam-Chon Paek
Journal:  Plant Physiol       Date:  2009-03-18       Impact factor: 8.340
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