Literature DB >> 12060787

KSR--a regulator and scaffold protein of the MAPK pathway.

Thomas Raabe1, Ulf R Rapp.   

Abstract

Raabe and Rapp discuss how the scaffolding proteins may spatially localize mitogen-activated protein kinase (MAPK) signaling cassettes to allow signaling specificity. They focus on the adaptor kinase suppressor of Ras (KSR) and describe how the interactions between KSR and other proteins and the subcellular localization of KSR are regulated by phosphorylation.

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Year:  2002        PMID： 12060787     DOI： 10.1126/stke.2002.136.pe28

Source DB:  PubMed          Journal:  Sci STKE        ISSN： 1525-8882


  12 in total

1.  Bimodal regulation of RAF by CNK in Drosophila.

Authors:  Mélanie Douziech; François Roy; Gino Laberge; Martin Lefrançois; Anne-Valérie Armengod; Marc Therrien
Journal:  EMBO J       Date:  2003-10-01       Impact factor: 11.598

2.  Drosophila Raf's N terminus contains a novel conserved region and can contribute to torso RTK signaling.

Authors:  Jian Ding; Oren Tchaicheeyan; Linda Ambrosio
Journal:  Genetics       Date:  2009-12-14       Impact factor: 4.562

Review 3.  KSR as a therapeutic target for Ras-dependent cancers.

Authors:  Beth K Neilsen; Danielle E Frodyma; Robert E Lewis; Kurt W Fisher
Journal:  Expert Opin Ther Targets       Date:  2017-04-07       Impact factor: 6.902

4.  MAPK Signaling Pathway Is Essential for Female Reproductive Regulation in the Cabbage Beetle, Colaphellus bowringi.

Authors:  Zijie Huang; Zhong Tian; Yulian Zhao; Fen Zhu; Wen Liu; Xiaoping Wang
Journal:  Cells       Date:  2022-05-10       Impact factor: 7.666

5.  Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase.

Authors:  John H Yoder; Huira Chong; Kun-Liang Guan; Min Han
Journal:  EMBO J       Date:  2003-12-11       Impact factor: 11.598

6.  Role of phosphatidic acid in the coupling of the ERK cascade.

Authors:  Catherine A Kraft; José Luis Garrido; Eric Fluharty; Luis Leiva-Vega; Guillermo Romero
Journal:  J Biol Chem       Date:  2008-10-24       Impact factor: 5.157

7.  The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse.

Authors:  Emanuele Giurisato; Joseph Lin; Angus Harding; Elisa Cerutti; Marina Cella; Robert E Lewis; Marco Colonna; Andrey S Shaw
Journal:  Mol Cell Biol       Date:  2009-01-12       Impact factor: 4.272

8.  Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.

Authors:  Tobias Sperka; Katja J Geissler; Ulrike Merkel; Ingmar Scholl; Ignacio Rubio; Peter Herrlich; Helen L Morrison
Journal:  PLoS One       Date:  2011-11-21       Impact factor: 3.240

9.  Aurora-A overexpression enhances cell-aggregation of Ha-ras transformants through the MEK/ERK signaling pathway.

Authors:  Ya-Shih Tseng; Jenq-Chang Lee; Chi-Ying F Huang; Hsiao-Sheng Liu
Journal:  BMC Cancer       Date:  2009-12-12       Impact factor: 4.430

10.  Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation.

Authors:  S Schweyer; A Soruri; O Meschter; A Heintze; F Zschunke; N Miosge; P Thelen; T Schlott; H J Radzun; A Fayyazi
Journal:  Br J Cancer       Date:  2004-08-02       Impact factor: 7.640
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