Literature DB >> 12058807

Influence of processing conditions in the manufacture of O/W creams: I. Effect on dispersion grade and rheological characteristics.

Nicola Realdon1, Francesco Perin, Margherita Morpurgo, Enrico Ragazzi.   

Abstract

Two series of O/W creams having the same general formulation were prepared in three different mechanical conditions (F with an hand blender; S with a turbomixer; T with a vacuum turbo emulsor) using two types of surfactants, polyoxyethylene-cetostearyl alcohols and polyglyceryl-3-methylglucose-distearate. By means of microscopic image analysis it was possible to point out the dispersion grade of the oil internal phase increasing with the energy applied under the conditions of manufacture (F < S < T). The level of dispersion influenced significantly on the rheological characteristics of the creams. With polyoxyethylene-cetostearyl alcohols, the viscosity of creams increased as the energy applied in manufacturing increased, with polyglyceryl-3-methylglucose-distearate on the contrary decreased. Moreover, indifferently to the manufacturing conditions, even in the same concentration of surfactant, the creams obtained with the last produced a much greater viscosity. At a parity of manufacturing conditions the differences between the batches of productions were not significant.

Entities:  

Mesh:

Substances:

Year:  2002        PMID: 12058807     DOI: 10.1016/s0014-827x(02)01213-2

Source DB:  PubMed          Journal:  Farmaco        ISSN: 0014-827X


  1 in total

Review 1.  Image Analysis: A Versatile Tool in the Manufacturing and Quality Control of Pharmaceutical Dosage Forms.

Authors:  Dóra Farkas; Lajos Madarász; Zsombor K Nagy; István Antal; Nikolett Kállai-Szabó
Journal:  Pharmaceutics       Date:  2021-05-10       Impact factor: 6.321

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.