Literature DB >> 12058102

Brainstem involvement in Unverricht-Lundborg disease (EPM1): An MRI and (1)H MRS study.

M Mascalchi1, R Michelucci, M Cosottini, C Tessa, F Lolli, P Riguzzi, A E Lehesjoki, M Tosetti, N Villari, C A Tassinari.   

Abstract

MRI of the brain and proton MRS ((1)H MRS) of the pons and dentate were obtained in 10 patients with genetically confirmed Unverricht-Lundborg disease (EPM1) and 20 control subjects. Patients with EPM1 showed (p < or = 0.01) loss of bulk of the basis pontis, medulla, and cerebellar hemispheres. Cerebral atrophy was present in six patients. The N-acetylaspartate/creatine and choline/creatine ratios were reduced in the pons but not in the dentate (p < or = 0.005). Brainstem involvement could play a role in pathophysiology of EPM1.

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Year:  2002        PMID： 12058102     DOI： 10.1212/wnl.58.11.1686

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  8 in total

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