| Literature DB >> 12058100 |
A S Chappell1, J W Sander, M J Brodie, D Chadwick, A Lledo, D Zhang, J Bjerke, G M Kiesler, S Arroyo.
Abstract
The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) with a median seizure reduction of 21%. Eighty percent of patients had fewer seizures on talampanel than on placebo. Dizziness (52%) and ataxia (26%) were the only significant adverse events.Entities:
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Year: 2002 PMID： 12058100 DOI： 10.1212/wnl.58.11.1680
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910